Please use this identifier to cite or link to this item:
doi:10.22028/D291-27512
Title: | Glucose and Fat Tolerance Tests Induce Differential Responses in Plasma Choline Metabolites in Healthy Subjects |
Author(s): | Obeid, Rima Awwad, Hussain M. Knell, Astrid Ines Hübner, Ulrich Geisel, Jürgen |
Language: | English |
Title: | Nutrients |
Volume: | 10 |
Publisher/Platform: | MDPI |
Year of Publication: | 2018 |
Free key words: | choline trimethylamine N-oxide diabetes methylation |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Plasma choline shows associations with plasma glucose and lipids. We studied changes of choline metabolites after oral glucose tolerance test (OGTT) and fat tolerance test (OFTT). Eighteen healthy subjects (mean age 54.3 years; BMI 26.8 kg/m2) underwent 2 tests. First, OFTT (80 g fat) was applied and blood was collected at baseline and 4 h after OFTT. Seven days later, 75 g glucose was applied and blood was collected at baseline and 2 h after OGTT. Plasma concentrations of choline, betaine, trimethylamine N-oxide (TMAO), dimethylglycine, S-adenosylmethionine (SAM), lipids and glucose were measured. After OFTT, plasma choline declined (10.6 to 9.2 µmol/L; p = 0.004), betaine declined (33.4 to 31.7 µmol/L; p = 0.003), TMAO slightly increased (4.1 to 5.6 µmol/L; p = 0.105), glucose declined (5.39 to 4.98 mmol/L; p < 0.001), and triglycerides increased (1.27 to 2.53 mmol/L; p < 0.001). After OGTT, plasma choline increased (10.1 to 11.1 µmol/L; p < 0.001), TMAO declined (4.0 to 3.5 µmol/L; p = 0.029), dimethylglycine declined (2.0 to 1.7 µmol/L; p = 0.005), SAM declined (103 to 96 nmol/L; p = 0.041), but betaine, glucose, and SAM were unchanged. In conclusion, OFTT lowered plasma betaine and choline and caused heterogeneous changes in plasma TMAO. OGTT reduced the flow of methyl groups and plasma TMAO. |
DOI of the first publication: | 10.3390/nu10091209 |
Link to this record: | urn:nbn:de:bsz:291--ds-275128 hdl:20.500.11880/28838 http://dx.doi.org/10.22028/D291-27512 |
ISSN: | 2072-6643 |
Date of registration: | 5-Mar-2020 |
Description of the related object: | Supplementary Material |
Related object: | https://www.mdpi.com/2072-6643/10/9/1209/s1 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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nutrients-10-01209-v2.pdf | 270,61 kB | Adobe PDF | View/Open |
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