Please use this identifier to cite or link to this item:
doi:10.22028/D291-27509
Title: | Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers |
Author(s): | Baek, In-Hyuk Han, Hyung-Seop Baik, Seungyun Helms, Volkhard Kim, Youngjun |
Language: | English |
Title: | Polymers |
Volume: | 10 |
Issue: | 9 |
Publisher/Platform: | MDPI |
Year of Publication: | 2018 |
Free key words: | molecularly imprinted polymer polypyrrole filamentous bacteriophage clofibric acid |
DDC notations: | 004 Computer science, internet |
Publikation type: | Journal Article |
Abstract: | Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds. |
DOI of the first publication: | 10.3390/polym10090974 |
Link to this record: | urn:nbn:de:bsz:291--ds-275095 hdl:20.500.11880/28759 http://dx.doi.org/10.22028/D291-27509 |
ISSN: | 2073-4360 |
Date of registration: | 20-Feb-2020 |
Description of the related object: | Supplementary Material |
Related object: | https://www.mdpi.com/2073-4360/10/9/974/s1 |
Faculty: | ZE - Zentrale Einrichtungen |
Department: | ZE - Zentrum für Bioinformatik(ZBI) |
Professorship: | ZE - Sonstige |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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polymers-10-00974-v2.pdf | 4,07 MB | Adobe PDF | View/Open |
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