Please use this identifier to cite or link to this item: doi:10.22028/D291-27509
Title: Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers
Author(s): Baek, In-Hyuk
Han, Hyung-Seop
Baik, Seungyun
Helms, Volkhard
Kim, Youngjun
Language: English
Title: Polymers
Volume: 10
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2018
Free key words: molecularly imprinted polymer
polypyrrole
filamentous bacteriophage
clofibric acid
DDC notations: 004 Computer science, internet
Publikation type: Journal Article
Abstract: Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds.
DOI of the first publication: 10.3390/polym10090974
Link to this record: urn:nbn:de:bsz:291--ds-275095
hdl:20.500.11880/28759
http://dx.doi.org/10.22028/D291-27509
ISSN: 2073-4360
Date of registration: 20-Feb-2020
Description of the related object: Supplementary Material
Related object: https://www.mdpi.com/2073-4360/10/9/974/s1
Faculty: ZE - Zentrale Einrichtungen
Department: ZE - Zentrum für Bioinformatik
Professorship: ZE - Sonstige
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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