Please use this identifier to cite or link to this item:
doi:10.22028/D291-27486
Title: | Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy |
Author(s): | Smola, Sigrun |
Language: | English |
Title: | Viruses |
Volume: | 9 |
Issue: | 9 |
Publisher/Platform: | MDPI |
Year of Publication: | 2017 |
Free key words: | human papillomavirus cervical cancer |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Recent studies have demonstrated that HPV-transformed cells actively promote chronic stromal inflammation and conspire with cells in the local microenvironment to promote carcinogenesis. This review highlights the complex interplay between HPV-infected cells and the local immune microenvironment during oncogenic HPV infection, persistence, and malignant progression, and discusses new prospects for diagnosis and immunotherapy of HPV-associated cancers. |
DOI of the first publication: | 10.3390/v9090254 |
Link to this record: | urn:nbn:de:bsz:291--ds-274864 hdl:20.500.11880/28593 http://dx.doi.org/10.22028/D291-27486 |
ISSN: | 1999-4915 |
Date of registration: | 17-Jan-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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viruses-09-00254.pdf | 1,03 MB | Adobe PDF | View/Open |
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