Please use this identifier to cite or link to this item: doi:10.22028/D291-27486
Title: Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy
Author(s): Smola, Sigrun
Language: English
Title: Viruses
Volume: 9
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2017
Free key words: human papillomavirus
cervical cancer
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Recent studies have demonstrated that HPV-transformed cells actively promote chronic stromal inflammation and conspire with cells in the local microenvironment to promote carcinogenesis. This review highlights the complex interplay between HPV-infected cells and the local immune microenvironment during oncogenic HPV infection, persistence, and malignant progression, and discusses new prospects for diagnosis and immunotherapy of HPV-associated cancers.
DOI of the first publication: 10.3390/v9090254
Link to this record: urn:nbn:de:bsz:291--ds-274864
ISSN: 1999-4915
Date of registration: 17-Jan-2020
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
viruses-09-00254.pdf1,03 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons