Please use this identifier to cite or link to this item:
doi:10.22028/D291-27438
Title: | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
Author(s): | Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus |
Language: | English |
Title: | Molecules |
Volume: | 19 |
Issue: | 9 |
Startpage: | 14902 |
Endpage: | 14918 |
Publisher/Platform: | MDPI |
Year of Publication: | 2014 |
DDC notations: | 540 Chemistry |
Publikation type: | Journal Article |
Abstract: | Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings. |
DOI of the first publication: | 10.3390/molecules190914902 |
Link to this record: | urn:nbn:de:bsz:291--ds-274380 hdl:20.500.11880/28533 http://dx.doi.org/10.22028/D291-27438 |
ISSN: | 1420-3049 |
Date of registration: | 3-Jan-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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molecules-19-14902-v2.pdf | 2,38 MB | Adobe PDF | View/Open |
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