Please use this identifier to cite or link to this item: doi:10.22028/D291-27438
Title: 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
Author(s): Klotz, Lars-Oliver
Hou, Xiaoqing
Jacob, Claus
Language: English
Title: Molecules
Volume: 19
Issue: 9
Startpage: 14902
Endpage: 14918
Publisher/Platform: MDPI
Year of Publication: 2014
DDC notations: 540 Chemistry
Publikation type: Journal Article
Abstract: Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
DOI of the first publication: 10.3390/molecules190914902
Link to this record: urn:nbn:de:bsz:291--ds-274380
ISSN: 1420-3049
Date of registration: 3-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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