Please use this identifier to cite or link to this item: doi:10.22028/D291-29614
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Title: Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue
Author(s): Peckys, Diana B.
Hirsch, Daniela
Gaiser, Timo
de Jonge, Niels
Language: English
Title: Molecular medicine : official journal of the Molecular Medicine Society
Volume: 25
Issue: 1
Startpage: 1
Endpage: 12
Publisher/Platform: Feinstein Institute for Medical Research
Year of Publication: 2019
Publikation type: Journal Article
Abstract: HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 staining of tumour tissue. However, the current immunohistochemical methods do not provide localized information about HER2's functional state. In order to generate signals leading to cell growth and proliferation, the receptor spontaneously forms homodimers, a process that can differ between individual cancer cells.
DOI of the first publication: 10.1186/s10020-019-0108-z
URL of the first publication:
Link to this record: hdl:20.500.11880/28226
ISSN: 1528-3658
Date of registration: 28-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Keiner Professur zugeordnet
Collections:Die Universitätsbibliographie

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