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|Title:||Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections|
|Author(s):||Günday Türeli, Nazende|
Schwarz, Bianca C.
Türeli, Akif Emre
|Title:||European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences|
|Year of Publication:||2017|
|Publikation type:||Journal Article|
|Abstract:||Current pulmonary treatments against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lung suffer from deactivation of the drug and immobilization in thick and viscous biofilm/mucus blend, along with the general antibiotic resistance. Administration of nanoparticles (NPs) with high antibiotic load capable of penetrating the tight mesh of biofilm/mucus can be an advent to overcome the treatment bottlenecks. Biodegradable and biocompatible polymer nanoparticles efficiently loaded with ciprofloxacin complex offer a solution for emerging treatment strategies. NPs were prepared under controlled conditions by utilizing MicroJet Reactor (MJR) to yield a particle size of 190.4±28.6nm with 0.089 PDI. Encapsulation efficiency of the drug was 79% resulting in a loading of 14%. Release was determined to be controlled and medium-independent in PBS, PBS+0.2% Tween 80 and simulated lung fluid. Cytotoxicity assays with Calu-3 cells and CF bronchial epithelial cells (CFBE41o-) indicated that complex-loaded PLGA NPs were non-toxic at concentrations ≫ MICcipro against lab strains of the bacteria. Antibacterial activity tests revealed enhanced activity when applied as nanoparticles. NPs' colloidal stability in mucus was proven. Notably, a decrease in mucus turbidity was observed upon incubation with NPs. Herewith, ciprofloxacin complex-loaded PLGA NPs are introduced as promising pulmonary nano drug delivery systems against P.aeruginosa infections in CF lung.|
|DOI of the first publication:||10.1016/j.ejpb.2017.04.032|
|URL of the first publication:||https://www.sciencedirect.com/science/article/abs/pii/S0939641116309924?via%3Dihub|
|Link to this record:||hdl:20.500.11880/27991|
|Date of registration:||1-Oct-2019|
|Faculty:||NT - Naturwissenschaftlich- Technische Fakultät|
|Department:||NT - Pharmazie|
|Professorship:||NT - Prof. Dr. Marc Schneider|
|Collections:||SciDok - Der Wissenschaftsserver der Universität des Saarlandes|
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