Please use this identifier to cite or link to this item: doi:10.22028/D291-29606
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Title: Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections
Author(s): Günday Türeli, Nazende
Torge, Afra
Juntke, Jenny
Schwarz, Bianca C.
Schneider-Daum, Nicole
Türeli, Akif Emre
Lehr, Claus-Michael
Schneider, Marc
Language: English
Title: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Volume: 117
Startpage: 363
Endpage: 371
Publisher/Platform: Elsevier
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Current pulmonary treatments against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lung suffer from deactivation of the drug and immobilization in thick and viscous biofilm/mucus blend, along with the general antibiotic resistance. Administration of nanoparticles (NPs) with high antibiotic load capable of penetrating the tight mesh of biofilm/mucus can be an advent to overcome the treatment bottlenecks. Biodegradable and biocompatible polymer nanoparticles efficiently loaded with ciprofloxacin complex offer a solution for emerging treatment strategies. NPs were prepared under controlled conditions by utilizing MicroJet Reactor (MJR) to yield a particle size of 190.4±28.6nm with 0.089 PDI. Encapsulation efficiency of the drug was 79% resulting in a loading of 14%. Release was determined to be controlled and medium-independent in PBS, PBS+0.2% Tween 80 and simulated lung fluid. Cytotoxicity assays with Calu-3 cells and CF bronchial epithelial cells (CFBE41o-) indicated that complex-loaded PLGA NPs were non-toxic at concentrations ≫ MICcipro against lab strains of the bacteria. Antibacterial activity tests revealed enhanced activity when applied as nanoparticles. NPs' colloidal stability in mucus was proven. Notably, a decrease in mucus turbidity was observed upon incubation with NPs. Herewith, ciprofloxacin complex-loaded PLGA NPs are introduced as promising pulmonary nano drug delivery systems against P.aeruginosa infections in CF lung.
DOI of the first publication: 10.1016/j.ejpb.2017.04.032
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0939641116309924?via%3Dihub
Link to this record: hdl:20.500.11880/27991
http://dx.doi.org/10.22028/D291-29606
ISSN: 1879-0720
0928-0987
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:UniBib – Die Universitätsbibliographie

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