Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-29606
Titel: | Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections |
VerfasserIn: | Günday Türeli, Nazende Torge, Afra Juntke, Jenny Schwarz, Bianca C. Schneider-Daum, Nicole Türeli, Akif Emre Lehr, Claus-Michael Schneider, Marc |
Sprache: | Englisch |
Titel: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences |
Bandnummer: | 117 |
Startseite: | 363 |
Endseite: | 371 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2017 |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Current pulmonary treatments against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lung suffer from deactivation of the drug and immobilization in thick and viscous biofilm/mucus blend, along with the general antibiotic resistance. Administration of nanoparticles (NPs) with high antibiotic load capable of penetrating the tight mesh of biofilm/mucus can be an advent to overcome the treatment bottlenecks. Biodegradable and biocompatible polymer nanoparticles efficiently loaded with ciprofloxacin complex offer a solution for emerging treatment strategies. NPs were prepared under controlled conditions by utilizing MicroJet Reactor (MJR) to yield a particle size of 190.4±28.6nm with 0.089 PDI. Encapsulation efficiency of the drug was 79% resulting in a loading of 14%. Release was determined to be controlled and medium-independent in PBS, PBS+0.2% Tween 80 and simulated lung fluid. Cytotoxicity assays with Calu-3 cells and CF bronchial epithelial cells (CFBE41o-) indicated that complex-loaded PLGA NPs were non-toxic at concentrations ≫ MICcipro against lab strains of the bacteria. Antibacterial activity tests revealed enhanced activity when applied as nanoparticles. NPs' colloidal stability in mucus was proven. Notably, a decrease in mucus turbidity was observed upon incubation with NPs. Herewith, ciprofloxacin complex-loaded PLGA NPs are introduced as promising pulmonary nano drug delivery systems against P.aeruginosa infections in CF lung. |
DOI der Erstveröffentlichung: | 10.1016/j.ejpb.2017.04.032 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/abs/pii/S0939641116309924?via%3Dihub |
Link zu diesem Datensatz: | hdl:20.500.11880/27991 http://dx.doi.org/10.22028/D291-29606 |
ISSN: | 1879-0720 0928-0987 |
Datum des Eintrags: | 1-Okt-2019 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Pharmazie |
Professur: | NT - Prof. Dr. Marc Schneider |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.