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doi:10.22028/D291-29593
Title: | Development of inhalable curcumin loaded Nano-in-Microparticles for bronchoscopic photodynamic therapy |
Author(s): | Baghdan, Elias Duse, Lili Schüer, Julia Janina Pinnapireddy, Shashank Reddy Pourasghar, Marcel Schäfer, Jens Schneider, Marc Bakowsky, Udo |
Language: | English |
Title: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences |
Volume: | 132 |
Startpage: | 63 |
Endpage: | 71 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2019 |
Publikation type: | Journal Article |
Abstract: | Photodynamic therapy is amongst the most rapidly developing therapeutic strategies against cancer. However, most photosensitizers are administered intravenously with very few reports about pulmonary applications. To address this issue, an inhalable formulation consisting of nanoparticles loaded with photosensitizer (i.e. curcumin) was developed. The nanoparticles were prepared using nanoprecipitation method. Dynamic light scattering measurements of the curcumin loaded nanoparticles revealed a hydrodynamic diameter of 181.20 ± 11.52 nm. In vitro irradiation experiments with human lung epithelial carcinoma cells (A549) showed a selective cellular toxicity of the nanoparticles upon activation using LED irradiating device. Moreover, curcumin nanoparticles exhibited a dose-dependent photocytotoxicity and the IC50 values of curcumin were directly dependent on the radiation fluence used. The nanoparticles were subsequently spray dried using mannitol as a stabilizer to produce Nano-in-Microparticles with appropriate aerodynamic properties for a sufficient deposition in the lungs. This was confirmed using the next generation impactor, which revealed a large fine particle fraction (64.94 ± 3.47%) and a mass median aerodynamic diameter of 3.02 ± 0.07 μm. Nano-in-Microparticles exhibited a good redispersibility and disintegrated into the original nanoparticles upon redispersion in aqueous medium. The Langmuir monolayer experiments revealed an excellent compatibility of the nanoparticles with the lung surfactant. Results from this study showed that the Nano-in-Microparticles are promising drug carriers for the photodynamic therapy of lung cancer. |
DOI of the first publication: | 10.1016/j.ejps.2019.02.025 |
URL of the first publication: | https://www.sciencedirect.com/science/article/abs/pii/S0928098719300867 |
Link to this record: | hdl:20.500.11880/27979 http://dx.doi.org/10.22028/D291-29593 |
ISSN: | 1879-0720 0928-0987 |
Date of registration: | 1-Oct-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Marc Schneider |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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