Please use this identifier to cite or link to this item: doi:10.22028/D291-29593
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Title: Development of inhalable curcumin loaded Nano-in-Microparticles for bronchoscopic photodynamic therapy
Author(s): Baghdan, Elias
Duse, Lili
Schüer, Julia Janina
Pinnapireddy, Shashank Reddy
Pourasghar, Marcel
Schäfer, Jens
Schneider, Marc
Bakowsky, Udo
Language: English
Title: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Volume: 132
Startpage: 63
Endpage: 71
Publisher/Platform: Elsevier
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Photodynamic therapy is amongst the most rapidly developing therapeutic strategies against cancer. However, most photosensitizers are administered intravenously with very few reports about pulmonary applications. To address this issue, an inhalable formulation consisting of nanoparticles loaded with photosensitizer (i.e. curcumin) was developed. The nanoparticles were prepared using nanoprecipitation method. Dynamic light scattering measurements of the curcumin loaded nanoparticles revealed a hydrodynamic diameter of 181.20 ± 11.52 nm. In vitro irradiation experiments with human lung epithelial carcinoma cells (A549) showed a selective cellular toxicity of the nanoparticles upon activation using LED irradiating device. Moreover, curcumin nanoparticles exhibited a dose-dependent photocytotoxicity and the IC50 values of curcumin were directly dependent on the radiation fluence used. The nanoparticles were subsequently spray dried using mannitol as a stabilizer to produce Nano-in-Microparticles with appropriate aerodynamic properties for a sufficient deposition in the lungs. This was confirmed using the next generation impactor, which revealed a large fine particle fraction (64.94 ± 3.47%) and a mass median aerodynamic diameter of 3.02 ± 0.07 μm. Nano-in-Microparticles exhibited a good redispersibility and disintegrated into the original nanoparticles upon redispersion in aqueous medium. The Langmuir monolayer experiments revealed an excellent compatibility of the nanoparticles with the lung surfactant. Results from this study showed that the Nano-in-Microparticles are promising drug carriers for the photodynamic therapy of lung cancer.
DOI of the first publication: 10.1016/j.ejps.2019.02.025
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0928098719300867
Link to this record: hdl:20.500.11880/27979
http://dx.doi.org/10.22028/D291-29593
ISSN: 1879-0720
0928-0987
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:UniBib – Die Universitätsbibliographie

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