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doi:10.22028/D291-29575
Title: | Combining cryo-TEM and energy-filtered TEM for imaging organic core-shell nanoparticles and defining the polymer distribution |
Author(s): | Weiss, Agnes-Valencia Koch, Marcus Schneider, Marc |
Language: | English |
Title: | International journal of pharmaceutics |
Volume: | 570 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2019 |
Publikation type: | Journal Article |
Abstract: | Nanoparticulate systems intended for the use in drug delivery are getting more and more complex. Composite nanoparticles, such as core-shell particles are designed in order to be used for co-delivery of drugs or a modified release profile. Often the structure can only be postulated by the preparation process, such as surface polymerization, but cannot be experimentally determined due to a lack of appropriate analytical methods. Here a core-shell particle system composed of two biodegradable and biocompatible materials, gelatin and PLGA, is developed. In order to reveal the actual polymer distribution, a combination of cryo-transmission electron microscopy and energy-filtered transmission electron microscopy was established. Using the occurrence of specific elements in combination with degradation kinetics induced by the electron beam allows to conclude on the nanoparticles' architecture. Based on these methods and thus, the particle composition, the drug delivery system can be further developed. |
DOI of the first publication: | 10.1016/j.ijpharm.2019.118650 |
URL of the first publication: | https://www.sciencedirect.com/science/article/pii/S0378517319306957 |
Link to this record: | hdl:20.500.11880/27969 http://dx.doi.org/10.22028/D291-29575 |
ISSN: | 1873-3476 0378-5173 |
Date of registration: | 30-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Marc Schneider |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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