Please use this identifier to cite or link to this item:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-29534
Title: | Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells |
Author(s): | Hammer, Quirin Rückert, Timo Borst, Eva Maria Dunst, Josefine Haubner, André Durek, Pawel Heinrich, Frederik Gasparoni, Gilles Babic, Marina Tomic, Adriana Pietra, Gabriella Nienen, Mikalai Blau, Igor Wolfgang Hofmann, Jörg Na, Il-Kang Prinz, Immo Koenecke, Christian Hemmati, Philipp Babel, Nina Arnold, Renate Walter, Jörn Erik Thurley, Kevin Mashreghi, Mir-Farzin Messerle, Martin Romagnani, Chiara |
Language: | English |
Title: | Nature immunology |
Volume: | 19 |
Issue: | 5 |
Startpage: | 453 |
Endpage: | 463 |
Publisher/Platform: | Nature Publishing Group |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C+ NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C+ NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C+ NK cell populations among HCMV-seropositive people. |
DOI of the first publication: | 10.1038/s41590-018-0082-6 |
Link to this record: | hdl:20.500.11880/27921 http://dx.doi.org/10.22028/D291-29534 |
ISSN: | 1529-2908 1529-2916 |
Date of registration: | 26-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Jörn Walter |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
There are no files associated with this item.
Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.