Please use this identifier to cite or link to this item: doi:10.22028/D291-29534
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Title: Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Author(s): Hammer, Quirin
Rückert, Timo
Borst, Eva Maria
Dunst, Josefine
Haubner, André
Durek, Pawel
Heinrich, Frederik
Gasparoni, Gilles
Babic, Marina
Tomic, Adriana
Pietra, Gabriella
Nienen, Mikalai
Blau, Igor Wolfgang
Hofmann, Jörg
Na, Il-Kang
Prinz, Immo
Koenecke, Christian
Hemmati, Philipp
Babel, Nina
Arnold, Renate
Walter, Jörn Erik
Thurley, Kevin
Mashreghi, Mir-Farzin
Messerle, Martin
Romagnani, Chiara
Language: English
Title: Nature immunology
Volume: 19
Issue: 5
Startpage: 453
Endpage: 463
Publisher/Platform: Nature Publishing Group
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C+ NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C+ NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C+ NK cell populations among HCMV-seropositive people.
DOI of the first publication: 10.1038/s41590-018-0082-6
Link to this record: hdl:20.500.11880/27921
ISSN: 1529-2908
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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