Please use this identifier to cite or link to this item:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-29527
Title: | LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells |
Author(s): | Lino, Andreia C. Dang, Van Duc Lampropoulou, Vicky Welle, Anna Joedicke, Jara Pohar, Jelka Simon, Quentin Thalmensi, Jessie Baures, Aurelia Flühler, Vinciane Sakwa, Imme Stervbo, Ulrik Ries, Stefanie Jouneau, Luc Boudinot, Pierre Tsubata, Takeshi Adachi, Takahiro Hutloff, Andreas Dörner, Thomas Zimber-Strobl, Ursula de Vos, Alex F. Dahlke, Katja Loh, Gunnar Korniotis, Sarantis Goosmann, Christian Weill, Jean-Claude Reynaud, Claude-Agnès Kaufmann, Stefan H. E. Walter, Jörn Erik Fillatreau, Simon |
Language: | English |
Title: | Immunity |
Volume: | 49 |
Issue: | 1 |
Startpage: | 120 |
Endpage: | 133 |
Publisher/Platform: | Cell Press |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention. |
DOI of the first publication: | 10.1016/j.immuni.2018.06.007 |
Link to this record: | hdl:20.500.11880/27915 http://dx.doi.org/10.22028/D291-29527 |
ISSN: | 1097-4180 1074-7613 |
Date of registration: | 26-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Jörn Walter |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
There are no files associated with this item.
Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.