Please use this identifier to cite or link to this item: doi:10.22028/D291-29527
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Title: LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
Author(s): Lino, Andreia C.
Dang, Van Duc
Lampropoulou, Vicky
Welle, Anna
Joedicke, Jara
Pohar, Jelka
Simon, Quentin
Thalmensi, Jessie
Baures, Aurelia
Flühler, Vinciane
Sakwa, Imme
Stervbo, Ulrik
Ries, Stefanie
Jouneau, Luc
Boudinot, Pierre
Tsubata, Takeshi
Adachi, Takahiro
Hutloff, Andreas
Dörner, Thomas
Zimber-Strobl, Ursula
de Vos, Alex F.
Dahlke, Katja
Loh, Gunnar
Korniotis, Sarantis
Goosmann, Christian
Weill, Jean-Claude
Reynaud, Claude-Agnès
Kaufmann, Stefan H. E.
Walter, Jörn Erik
Fillatreau, Simon
Language: English
Title: Immunity
Volume: 49
Issue: 1
Startpage: 120
Endpage: 133
Publisher/Platform: Cell Press
Year of Publication: 2018
Publikation type: Journal Article
Abstract: B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention.
DOI of the first publication: 10.1016/j.immuni.2018.06.007
Link to this record: hdl:20.500.11880/27915
http://dx.doi.org/10.22028/D291-29527
ISSN: 1097-4180
1074-7613
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:UniBib – Die Universitätsbibliographie

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