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doi:10.22028/D291-29526 | Title: | DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex |
| Author(s): | Gasparoni, Gilles Bultmann, Sebastian Lutsik, Pavlo Kraus, Theo F. J. Sordon, Sabrina Vlcek, Julia Dietinger, Vanessa Steinmaurer, Martina Haider, Melanie Mulholland, Christopher B. Arzberger, Thomas Roeber, Sigrun Riemenschneider, Matthias Kretzschmar, Hans A. Giese, Armin Leonhardt, Heinrich Walter, Jörn Erik |
| Language: | English |
| Title: | Epigenetics & chromatin |
| Volume: | 11 |
| Issue: | 1 |
| Publisher/Platform: | BioMed Central |
| Year of Publication: | 2018 |
| Publikation type: | Journal Article |
| Abstract: | Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem human brain tissues. |
| DOI of the first publication: | 10.1186/s13072-018-0211-3 |
| Link to this record: | hdl:20.500.11880/27914 http://dx.doi.org/10.22028/D291-29526 |
| ISSN: | 1756-8935 |
| Date of registration: | 26-Sep-2019 |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Biowissenschaften |
| Professorship: | NT - Prof. Dr. Jörn Walter |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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