Please use this identifier to cite or link to this item: doi:10.22028/D291-29526
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Title: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
Author(s): Gasparoni, Gilles
Bultmann, Sebastian
Lutsik, Pavlo
Kraus, Theo F. J.
Sordon, Sabrina
Vlcek, Julia
Dietinger, Vanessa
Steinmaurer, Martina
Haider, Melanie
Mulholland, Christopher B.
Arzberger, Thomas
Roeber, Sigrun
Riemenschneider, Matthias
Kretzschmar, Hans A.
Giese, Armin
Leonhardt, Heinrich
Walter, Jörn Erik
Language: English
Title: Epigenetics & chromatin
Volume: 11
Issue: 1
Publisher/Platform: BioMed Central
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem human brain tissues.
DOI of the first publication: 10.1186/s13072-018-0211-3
Link to this record: hdl:20.500.11880/27914
ISSN: 1756-8935
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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