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doi:10.22028/D291-29444
Title: | Integrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters |
Author(s): | Behjati Ardakani, Fatemeh Kattler, Kathrin Nordström, Karl Gasparoni, Nina Gasparoni, Gilles Fuchs, Sarah Sinha, Anupam Barann, Matthias Ebert, Peter Fischer, Jonas Hutter, Barbara Zipprich, Gideon Imbusch, Charles D. Felder, Bärbel Eils, Jürgen Brors, Benedikt Lengauer, Thomas Manke, Thomas Rosenstiel, Philip Walter, Jörn Erik Schulz, Marcel H. |
Language: | English |
Title: | Epigenetics & chromatin |
Volume: | 11 |
Issue: | 1 |
Publisher/Platform: | BioMed Central |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | Bidirectional promoters (BPs) are prevalent in eukaryotic genomes. However, it is poorly understood how the cell integrates different epigenomic information, such as transcription factor (TF) binding and chromatin marks, to drive gene expression at BPs. Single-cell sequencing technologies are revolutionizing the field of genome biology. Therefore, this study focuses on the integration of single-cell RNA-seq data with bulk ChIP-seq and other epigenetics data, for which single-cell technologies are not yet established, in the context of BPs. |
DOI of the first publication: | 10.1186/s13072-018-0236-7 |
Link to this record: | hdl:20.500.11880/27898 http://dx.doi.org/10.22028/D291-29444 |
ISSN: | 1756-8935 |
Date of registration: | 25-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Jörn Walter |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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