Please use this identifier to cite or link to this item: doi:10.22028/D291-29444
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Title: Integrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters
Author(s): Behjati Ardakani, Fatemeh
Kattler, Kathrin
Nordström, Karl
Gasparoni, Nina
Gasparoni, Gilles
Fuchs, Sarah
Sinha, Anupam
Barann, Matthias
Ebert, Peter
Fischer, Jonas
Hutter, Barbara
Zipprich, Gideon
Imbusch, Charles D.
Felder, Bärbel
Eils, Jürgen
Brors, Benedikt
Lengauer, Thomas
Manke, Thomas
Rosenstiel, Philip
Walter, Jörn Erik
Schulz, Marcel H.
Language: English
Title: Epigenetics & chromatin
Volume: 11
Issue: 1
Publisher/Platform: BioMed Central
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Bidirectional promoters (BPs) are prevalent in eukaryotic genomes. However, it is poorly understood how the cell integrates different epigenomic information, such as transcription factor (TF) binding and chromatin marks, to drive gene expression at BPs. Single-cell sequencing technologies are revolutionizing the field of genome biology. Therefore, this study focuses on the integration of single-cell RNA-seq data with bulk ChIP-seq and other epigenetics data, for which single-cell technologies are not yet established, in the context of BPs.
DOI of the first publication: 10.1186/s13072-018-0236-7
Link to this record: hdl:20.500.11880/27898
ISSN: 1756-8935
Date of registration: 25-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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