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doi:10.22028/D291-29381
Title: | Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla |
Author(s): | Witte, Swjatoslaw N. R. Hug, Joachim Josef Géraldy, Magalie N. E. Müller, Rolf Kalesse, Markus |
Language: | English |
Title: | Chemistry |
Volume: | 23 |
Issue: | 63 |
Startpage: | 15917 |
Endpage: | 15921 |
Publisher/Platform: | MDPI |
Year of Publication: | 2017 |
Publikation type: | Journal Article |
Abstract: | The first stereoselective total synthesis of the natural product pyrronazol B, which contains a chlorinated pyrrole-oxazole-pyrone framework, has been achieved. Genome sequencing of the myxobacterial producer strain Nannocystis pusilla Ari7 led to the identification of the putative biosynthetic gene cluster. The proposed biosynthetic pathway was supported by feeding experiments with stable isotopes of three biosynthetic building blocks, namely l-proline, l-serine, and l-methionine. |
DOI of the first publication: | 10.1002/chem.201703782 |
Link to this record: | hdl:20.500.11880/27868 http://dx.doi.org/10.22028/D291-29381 |
ISSN: | 2624-8549 |
Date of registration: | 24-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Rolf Müller |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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