Please use this identifier to cite or link to this item: doi:10.22028/D291-29381
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Title: Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla
Author(s): Witte, Swjatoslaw N. R.
Hug, Joachim Josef
Géraldy, Magalie N. E.
Müller, Rolf
Kalesse, Markus
Language: English
Title: Chemistry
Volume: 23
Issue: 63
Startpage: 15917
Endpage: 15921
Publisher/Platform: MDPI
Year of Publication: 2017
Publikation type: Journal Article
Abstract: The first stereoselective total synthesis of the natural product pyrronazol B, which contains a chlorinated pyrrole-oxazole-pyrone framework, has been achieved. Genome sequencing of the myxobacterial producer strain Nannocystis pusilla Ari7 led to the identification of the putative biosynthetic gene cluster. The proposed biosynthetic pathway was supported by feeding experiments with stable isotopes of three biosynthetic building blocks, namely l-proline, l-serine, and l-methionine.
DOI of the first publication: 10.1002/chem.201703782
Link to this record: hdl:20.500.11880/27868
ISSN: 2624-8549
Date of registration: 24-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Rolf Müller
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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