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doi:10.22028/D291-28063
Title: | Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27−CD28−CD4+ T Cells |
Author(s): | Burton, Catherine E Sester, Martina Robinson, Joan L Eurich, Dean T Preiksaitis, Jutta K Urschel, Simon |
Language: | English |
Title: | The Journal of Infectious Diseases |
Volume: | 218 |
Issue: | 8 |
Publisher/Platform: | Oxford University Press |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | Passive antibodies, maternal or transfusion-acquired, make serologic determination of pretransplant cytomegalovirus (CMV) status unreliable. We evaluated 3 assays unaffected by passive antibodies, in assignment of CMV infection status in children awaiting solid organ transplant and in controls: (1) CMV nucleic acid amplification testing (NAAT), (2) quantification of CMV-specific CD4+ T cells, and (3) quantification of CD27-CD28-CD4+ T cells. Our results highlight that CMV NAAT, from urine and oropharynx, is useful in confirming positive CMV status. Detection of CMV-specific CD4+ T cells was sensitive and specific in children >18 months but was less sensitive in children <12 months. CD27-CD28-CD4+ T cells are not likely useful in CMV risk stratification in children. |
DOI of the first publication: | 10.1093/infdis/jiy309 |
URL of the first publication: | https://www.ncbi.nlm.nih.gov/pubmed/29800231 |
Link to this record: | hdl:20.500.11880/27662 http://dx.doi.org/10.22028/D291-28063 |
ISSN: | 0022-1899 1537-6613 |
Date of registration: | 17-Aug-2019 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin |
Professorship: | M - Prof. Dr. Martina Sester |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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