Please use this identifier to cite or link to this item: doi:10.22028/D291-28063
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Title: Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27−CD28−CD4+ T Cells
Author(s): Burton, Catherine E
Sester, Martina
Robinson, Joan L
Eurich, Dean T
Preiksaitis, Jutta K
Urschel, Simon
Language: English
Title: The Journal of Infectious Diseases
Volume: 218
Issue: 8
Publisher/Platform: Oxford University Press
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Passive antibodies, maternal or transfusion-acquired, make serologic determination of pretransplant cytomegalovirus (CMV) status unreliable. We evaluated 3 assays unaffected by passive antibodies, in assignment of CMV infection status in children awaiting solid organ transplant and in controls: (1) CMV nucleic acid amplification testing (NAAT), (2) quantification of CMV-specific CD4+ T cells, and (3) quantification of CD27-CD28-CD4+ T cells. Our results highlight that CMV NAAT, from urine and oropharynx, is useful in confirming positive CMV status. Detection of CMV-specific CD4+ T cells was sensitive and specific in children >18 months but was less sensitive in children <12 months. CD27-CD28-CD4+ T cells are not likely useful in CMV risk stratification in children.
DOI of the first publication: 10.1093/infdis/jiy309
URL of the first publication:
Link to this record: hdl:20.500.11880/27662
ISSN: 0022-1899
Date of registration: 17-Aug-2019
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
Professorship: M - Prof. Dr. Martina Sester
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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