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doi:10.22028/D291-22883 | Title: | Expression of human CYP3A enzymes and drug metabolite production with fission yeast |
| Other Titles: | Expression humaner CYP3A-Enzyme und Produktion von Wirkstoffmetaboliten mit Spalthefe |
| Author(s): | Neunzig, Ina |
| Language: | English |
| Year of Publication: | 2013 |
| SWD key words: | Biotransformation Biotechnologie Cytochrom P-450 Protein CYP3A4 Schizosaccharomyces |
| Free key words: | Fremdstoffmetabolismus Polymorphismen Wirkstoffmetabolite Spalthefe drug metabolism polymorphism drug metabolite biotechnology |
| DDC notations: | 570 Life sciences, biology |
| Publikation type: | Dissertation |
| Abstract: | Expression of human CYP enzymes in fission yeast and enzyme opimization by usage of polymorphisms CYP3A4*18 and CYP3A7*2. Production of 4-hydroxydiclofenac and 3-hydroxyibuprofen. CPR from Ammi majus and S. pombe as electron-transfer protein for human CYPs in the whole-cell system. Expression humaner CYP Enzyme in Spalthefe und Produktion von Wirkstoffmetabolite mit Spalthefe. Polymorphismen aus CYP3A4 und CYP3A7 wurden zur Verbesserung der Biotransformationsraten eingeführt. Produktion von 4-Hydroxydiclofenac und 3-Hydroxyibuprofen und coexpression artfremder Reduktasen im Ganzzellsystem. |
| Link to this record: | urn:nbn:de:bsz:291-scidok-54424 hdl:20.500.11880/22939 http://dx.doi.org/10.22028/D291-22883 |
| Advisor: | Bureik, Matthias |
| Date of oral examination: | 3-Jul-2013 |
| Date of registration: | 5-Jul-2013 |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Biowissenschaften |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dissertation_IN_v4_final.pdf | 270,51 MB | Adobe PDF | View/Open |
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