Please use this identifier to cite or link to this item:
doi:10.22028/D291-21007
Title: | Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS |
Author(s): | Preuss, Klaus-Dieter Held, Gerhard Kubuschok, Boris Hung, Chun-Zhu Malatsidze, Natalia Wagner, Mathias Pfreundschuh, Michael |
Language: | German |
Year of Publication: | 2007 |
OPUS Source: | International journal of cancer. - 121. 2007, 2, S. 459-461 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins have been suggested to play an important role as growth stimulators in the pathogenesis of these neoplasms. To identify such targets, we screened cDNA libraries from human testis, lung and breast cancer, bovine and porcine muscle and wheat germ for reactivity with paraproteins in the sera from 115 patients with MGUS and MM. Of >6 x 10(8) paraprotein-antigen interactions screened, an IgA paraprotein from a female patient bound to sperm-specific cylicin-2, and 3 IgG paraproteins bound to tripeptidyl-peptidase-II (TPP-2), insulin-like growth-factor binding-protein-2 (IGFBP-2) and porcine kinesin. Specificity was confirmed by reverse Western blots using recombinant antigens. The broad spectrum of auto-, allo- and heteroantigens as targets of human paraproteins in patients without signs of chronic antigenic stimulation renders a causal role of the antigenic stimulus in the pathogenesis of MGUS and MM unlikely. |
Link to this record: | urn:nbn:de:bsz:291-scidok-15397 hdl:20.500.11880/21063 http://dx.doi.org/10.22028/D291-21007 |
Date of registration: | 15-May-2008 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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antigenic_targets_in_mgus_mm.pdf | 118,69 kB | Adobe PDF | View/Open |
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