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Titel: Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS
Verfasser: Preuss, Klaus-Dieter
Held, Gerhard
Kubuschok, Boris
Hung, Chun-Zhu
Malatsidze, Natalia
Wagner, Mathias
Pfreundschuh, Michael
Sprache: Deutsch
Erscheinungsjahr: 2007
Quelle: International journal of cancer. - 121. 2007, 2, S. 459-461
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumentart : Journalartikel
Kurzfassung: Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins have been suggested to play an important role as growth stimulators in the pathogenesis of these neoplasms. To identify such targets, we screened cDNA libraries from human testis, lung and breast cancer, bovine and porcine muscle and wheat germ for reactivity with paraproteins in the sera from 115 patients with MGUS and MM. Of >6 x 10(8) paraprotein-antigen interactions screened, an IgA paraprotein from a female patient bound to sperm-specific cylicin-2, and 3 IgG paraproteins bound to tripeptidyl-peptidase-II (TPP-2), insulin-like growth-factor binding-protein-2 (IGFBP-2) and porcine kinesin. Specificity was confirmed by reverse Western blots using recombinant antigens. The broad spectrum of auto-, allo- and heteroantigens as targets of human paraproteins in patients without signs of chronic antigenic stimulation renders a causal role of the antigenic stimulus in the pathogenesis of MGUS and MM unlikely.
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-15397
hdl:20.500.11880/21063
http://dx.doi.org/10.22028/D291-21007
SciDok-Publikation: 15-Mai-2008
Fakultät: Fakultät 2 - Medizin
Fachrichtung: M - Innere Medizin
Fakultät / Institution:M - Medizinische Fakultät

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