Please use this identifier to cite or link to this item: doi:10.22028/D291-21007
Title: Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS
Author(s): Preuss, Klaus-Dieter
Held, Gerhard
Kubuschok, Boris
Hung, Chun-Zhu
Malatsidze, Natalia
Wagner, Mathias
Pfreundschuh, Michael
Language: German
Year of Publication: 2007
OPUS Source: International journal of cancer. - 121. 2007, 2, S. 459-461
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins have been suggested to play an important role as growth stimulators in the pathogenesis of these neoplasms. To identify such targets, we screened cDNA libraries from human testis, lung and breast cancer, bovine and porcine muscle and wheat germ for reactivity with paraproteins in the sera from 115 patients with MGUS and MM. Of >6 x 10(8) paraprotein-antigen interactions screened, an IgA paraprotein from a female patient bound to sperm-specific cylicin-2, and 3 IgG paraproteins bound to tripeptidyl-peptidase-II (TPP-2), insulin-like growth-factor binding-protein-2 (IGFBP-2) and porcine kinesin. Specificity was confirmed by reverse Western blots using recombinant antigens. The broad spectrum of auto-, allo- and heteroantigens as targets of human paraproteins in patients without signs of chronic antigenic stimulation renders a causal role of the antigenic stimulus in the pathogenesis of MGUS and MM unlikely.
Link to this record: urn:nbn:de:bsz:291-scidok-15397
Date of registration: 15-May-2008
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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