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Titel: Effect of transforming growth factor-ß1 (TGF-ß1) released from a scaffold on chondrogenesis in an osteochondral defect model in the rabbit
Verfasser: Cucchiarini, Magali
Sohier, Jerome
Mitosch, Karin
Kaul, Gunter
Zurakowski, David
Bezemer, Jeroen M.
Kohn, Dieter
Madry, Henning
Sprache: Deutsch
Erscheinungsjahr: 2006
Quelle: Central european journal of biology. - 1. 2006, 1, S. 43-60
DDC-Sachgruppe: 570 Biowissenschaften, Biologie
Dokumentart : Journalartikel
Kurzfassung: Articular cartilage repair might be stimulated by the controlled delivery of therapeutic factors. We tested the hypotheses whether TGF-ß1 can be released from a polymeric scaffold over a prolonged period of time in vitro and whether its transplantation modulates cartilage repair in vivo. Unloaded control or TGF-ß1 poly(ether-ester) copolymeric scaffolds were applied to osteochondral defects in the knee joints of rabbits. In vitro, a cumulative dose of 9 ng TGF-ß1 was released over 4 weeks. In vivo, there were no adverse effects on the synovial membrane. Defects treated with TGF-ß1 scaffolds showed no significant difference in individual parameters of chondrogenesis and in the average cartilage repair score after 3 weeks. There was a trend towards a smaller area (42.5 %) of the repair tissue that stained positive for safranin O in defects receiving TGF-ß1 scaffolds. The data indicate that TGF-ß1 is released from emulsioncoated scaffolds over a prolonged period of time in vitro and that application of these scaffolds does not significantly modulate cartilage repair after 3 weeks in vivo. Future studies need to address the importance of TGF-ß1 dose and release rate to modulate chondrogenesis.
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-14967
hdl:20.500.11880/21033
http://dx.doi.org/10.22028/D291-20977
SciDok-Publikation: 23-Apr-2008
Fakultät: Fakultät 2 - Medizin
Fachrichtung: M - Orthopädie
Fakultät / Institution:M - Medizinische Fakultät

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