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Titel: Cardiovascular Risk and Its Presentation in Chronic Kidney Disease
VerfasserIn: Schunk, Stefan J.
Zimmermann, Paul
Sprache: Englisch
Titel: Journal of Clinical Medicine
Bandnummer: 14
Heft: 13
Verlag/Plattform: MDPI
Erscheinungsjahr: 2025
Freie Schlagwörter: chronic kidney disease
cardiovascular risk
cardiovascular biomarkers
coronary arterial disease
inflammation
renin–angiotensin–aldosterone system
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background/Objectives: Patients with chronic kidney disease (CKD) are associated with a significantly elevated cardiovascular risk. The incidence and prevalence of mediated cardiac disorders and major adverse cardiac events (MACEs), such as heart failure, arrhyth mias, acute coronary syndrome (ACS) based on coronary artery disease (CAD), stroke, venous thromboembolism, and peripheral artery disease, are significantly higher in CKD patients as compared with the general population. Methods: This narrative review sum marizes the current clinical understanding, the pathophysiological mechanisms, and the clinical consequences in the context of cardiovascular risk and disease in CKD. Results: The impact of CKD on mediated cardiovascular disorders and elevated MACE prevalence is complex and multifactorial. The underlying mechanisms involve various traditional cardiovascular risk factors, such as arterial hypertension, smoking, dyslipidemia, and diabetes. Furthermore, CKD-specific molecular and pathophysiological factors, such as chronic inflammation and associated oxidative stress and endothelial cell dysfunction, pro-coagulatory status, uremic toxins and uremic lipids, progressive vascular calcification, and alterations in the regulation of the renin–angiotensin–aldosterone system (RAAS) and sympathetic activation cause an increased cardiovascular risk. Conclusions: Understand ing the complex disease mechanisms between CKD and elevated cardiovascular risk might contribute to optimizing individual patients’ risk stratification and result in individualized diagnostic and treatment strategies via appropriate clinical biomarker application and individualized anti-inflammatory approaches.
DOI der Erstveröffentlichung: 10.3390/jcm14134567
URL der Erstveröffentlichung: https://doi.org/10.3390/jcm14134567
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-458558
hdl:20.500.11880/40276
http://dx.doi.org/10.22028/D291-45855
ISSN: 2077-0383
Datum des Eintrags: 23-Jul-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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