Please use this identifier to cite or link to this item: doi:10.22028/D291-45474
Title: Limitations and perspectives of the novel salivary test for endometriosis: an open web-based survey study of German gynecologic healthcare providers
Author(s): Nigdelis, Meletios P.
Doerk, Merle
Burghaus, Stefanie
Sillem, Martin
Hamoud, Bashar Haj
Solomayer, Erich‑Franz
Olmes, Gregor Leonhard
Language: English
Title: Archives of Gynecology and Obstetrics
Volume: 311 (2025)
Issue: 4
Pages: 1101-1109
Publisher/Platform: Springer Nature
Year of Publication: 2024
Free key words: Endometriosis
Salivary test
miRNA
Non-invasive diagnosis
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Introduction The description of a salivary miRNA signature for endometriosis has led to the development of a non-invasive diagnostic test. Current healthcare provider practices regarding the test remain uncaptured. The application of this test in practice was examined in a web-based survey, with the aim to provide their opinions on it. Methods We conducted an open web-based survey study between November 2023 and January 2024. Members of the German society of gynecologic endoscopy (Arbeitsgemeinschaft gynäkologische Endoskopie, AGE), society of endometriosis (Arbeitsgemeinschaft Endometriose, AGEM), and the endometriosis research foundation (Stiftung Endometriose Forschung, SEF) were contacted per e-mail twice. Participants’ data were anonymized. Diferences in responses based on self-reported expertise in the feld (basic knowledge, specialized knowledge, expert) were assessed using the χ2 -test or Fisher’s exact test. Statistical signifcance was set as p<0.05. Results In total 141 of 190 respondents completely responded to the survey (>75% of the questions of the survey). Twentyone physicians reported having experience with the test, while most participants had at least specialized knowledge on the feld (112/141). In terms of specifc questions, more than 90% found the costs high; almost 85% did not believe that the test replaces standard diagnostic tools (histology, clinical examination, and sonography). Eighty-six providers supported the use of the test in adolescents. Gynecologists with basic knowledge had a more positive attitude compared with more experienced ones in terms of usefulness (Fisher’s exact test, p<0.001). Signifcant diferences were demonstrated between expertise groups regarding (not only) applicability in adolescents (Fisher’s exact test, p=0.004), and using the test for screening purposes (χ2 -test, p=0.002). Discussion Despite the promising benefts of a salivary test for endometriosis, German healthcare providers would not change current practices. Nevertheless, less experienced colleagues were more positive towards the test.
DOI of the first publication: 10.1007/s00404-024-07601-3
URL of the first publication: https://doi.org/10.1007/s00404-024-07601-3
Link to this record: urn:nbn:de:bsz:291--ds-454746
hdl:20.500.11880/40065
http://dx.doi.org/10.22028/D291-45474
ISSN: 1432-0711
Date of registration: 30-May-2025
Description of the related object: Supplementary Information
Related object: https://static-content.springer.com/esm/art%3A10.1007%2Fs00404-024-07601-3/MediaObjects/404_2024_7601_MOESM1_ESM.docx
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
Professorship: M - Prof. Dr. E.-F. Solomayer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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