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Titel: Association Between Stroke and Traumatic Brain Injury: A Systematic Review and Meta-Analysis
VerfasserIn: Al-Salihi, Mohammed Maan
Al-Jebur, Maryam Sabah
Abd Elazim, Ahmed
Saha, Ram
Saleh, Ahmed
Siddiq, Farhan
Ayyad, Ali
Qureshi, Adnan I.
Sprache: Englisch
Titel: NeuroSci
Bandnummer: 6
Heft: 1
Verlag/Plattform: MDPI
Erscheinungsjahr: 2025
Freie Schlagwörter: traumatic brain injury
stroke
risk association
meta-analysis
systematic review
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Stroke and traumatic brain injury (TBI) represent two major health concerns worldwide. There is growing evidence suggesting a potential association between TBI and stroke. In this systematic review and meta-analysis, we aim to explore the association between TBI and stroke risk, with a specific focus on overall stroke risk and subgroup variations based on stroke type, severity, and the post-TBI time period. Methods: PubMed, Web of Science (WOS), Scopus, and Cochrane Library were systematically searched for studies exploring the link between stroke and TBI. The pooled hazard ratios (HRs) with a 95% confidence interval (CI) were calculated. The Comprehensive Meta-Analysis (CMA) software was used for the analysis. Subgroup analyses were conducted based on stroke type, TBI severity, and post-TBI phase. The Newcastle–Ottawa Scale (NOS) was utilized for the quality assessment. Results: We included a total of 13 observational studies, with data from 8 studies used for quantitative analysis. A history of TBI was associated with a significantly higher odds of stroke compared to controls (HR = 2.3, 95% CI (1.79 to 2.958), p < 0.001). The risk was greater for hemorrhagic stroke (HR = 4.8, 95% CI (3.336 to 6.942), p < 0.001) than for ischemic stroke (HR = 1.56, 95% CI (1.28 to 1.9), p < 0.001). Both moderate-to-severe TBI (HR = 3.64, 95% CI (2.158 to 6.142), p < 0.001) and mild TBI (HR = 1.81, 95% CI (1.17 to 2.8), p = 0.007) were associated with a significantly higher risk of stroke. The risk was also higher in the early post-TBI phase (1–30 days) (HR = 4.155, 95% CI (2.25 to 7.67), p < 0.001) compared to later phases (HR = 1.68, 95% CI (1.089 to 2.59), p = 0.019) from 30 days to 1 year and (HR = 1.87, 95% CI (1.375 to 2.544), p < 0.001) after 1 year. Conclusions: This systematic review confirms a significant association between TBI and an increased risk of stroke, regardless of TBI severity, type, or timing of stroke. The findings highlight the need for early monitoring and advocating preventive strategies for stroke in patients with a history of TBI.
DOI der Erstveröffentlichung: 10.3390/neurosci6010021
URL der Erstveröffentlichung: https://doi.org/10.3390/neurosci6010021
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-448355
hdl:20.500.11880/39854
http://dx.doi.org/10.22028/D291-44835
ISSN: 2673-4087
Datum des Eintrags: 27-Mär-2025
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/neurosci6010021/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Neurochirurgie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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