Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-44401
Titel: Cyclic regulation of Trpm4 expression in female vomeronasal neurons driven by ovarian sex hormones
VerfasserIn: Eckstein, Eugenia
Pyrski, Martina
Pinto, Silvia
Freichel, Marc
Vennekens, Rudi
Zufall, Frank
Sprache: Englisch
Titel: Molecular and cellular neuroscience : MCN
Bandnummer: 105
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
Freie Schlagwörter: Trpm4-IRES-Cre
Trpm5
Pheromone sensing
Olfactory
Aromatase
Exemestane
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The vomeronasal organ (VNO), the sensory organ of the mammalian accessory olfactory system, mediates the activation of sexually dimorphic reproductive behavioral and endocrine responses in males and females. It is unclear how sexually dimorphic and state-dependent responses are generated by vomeronasal sensory neurons (VSNs). Here, we report the expression of the transient receptor potential (TRP) channel Trpm4, a Ca2+-activated monovalent cation channel, as a second TRP channel present in mouse VSNs, in addition to the diacylglycerol-sensitive Trpc2 channel. The expression of Trpm4 in the mouse VNO is sexually dimorphic and, in females, is tightly linked to their reproductive cycle. We show that Trpm4 protein expression is upregulated specifically during proestrus and estrus, when female mice are about to ovulate and become sexually active and receptive. The cyclic regulation of Trpm4 expression in female VSNs depends on ovarian sex hormones and is abolished by surgical removal of the ovaries (OVX). Trpm4 upregulation can be restored in OVX mice by systemic treatment with 17ß-estradiol, requires endogenous activity of aromatase enzyme, and is strongly reduced during late pregnancy. This cyclic regulation of Trpm4 offers a neural mechanism by which female mice could regulate the relative strength of sensory signals in their VSNs, depending on hormonal state. Trpm4 is likely to participate in sex-specific, estrous cycle-dependent and sex hormone-regulated functions of the VNO, and may serve as a previously unknown genetic substrate for dissecting mammalian sexually dimorphic cellular and behavioral responses.
DOI der Erstveröffentlichung: 10.1016/j.mcn.2020.103495
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/pii/S1044743119302994
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-444011
hdl:20.500.11880/39686
http://dx.doi.org/10.22028/D291-44401
ISSN: 1095-9327
1044-7431
Datum des Eintrags: 18-Feb-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Frank Zufall
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
1-s2.0-S1044743119302994-main.pdf7,37 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons