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Titel: Therapeutic apheresis within immune-mediated neurological disorders: dosing and its effectiveness
VerfasserIn: Klingele, Matthias
Allmendinger, Carina
Thieme, Solmaz
Baerens, Lea
Fliser, Danilo
Jan, Bürmann
Sprache: Englisch
Titel: Scientific reports
Bandnummer: 10
Heft: 1
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2020
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Plasma exchange (PE) and immunoadsorption (IA) are standard therapeutic options of immune-mediated neurological disorders. This study evaluates the relation of the relative quantity of applied dose of PE and/ or IA and its achieved therapeutic effectiveness within the treated underlying neurological disorders. In a retrospective study, we evaluated data from PE and IA carried out 09/2009-06/2014 in neurological patients at the University-Hospital of Saarland, Germany. Apheresis dose was defined as the ratio of the extracorporeal treated plasma volume to the patient's plasma volume. Effectiveness was assessed through disease-specific tests and scores by the attending neurologist(s); results were classified into response or no response. 1101 apheresis (PE:238, IA:863), in 153 hospital-stays were carried out, averaged, 7.0 treatments per patients, 82% responded, 18% not. Mean applied apheresis dose per treatment was 0.91 with mean doses of 1.16 for PE and 0.81 for IA. The totally applied mean dose per stay was 5.6 (PE:5.01, IA:5.81). No correlation was seen between apheresis dosing and treatment effectiveness (PE:R2 = 0.074, IA:R2 = 0.0023). PE and IA in therapy-refractory immune-mediated neurological disorders majorly achieved a measurable severity improvement - without correlation to the applied dose. Moreover, our data rather suggest, that effectiveness may be given with volumes below currently recommended volumes.
DOI der Erstveröffentlichung: 10.1038/s41598-020-64744-4
URL der Erstveröffentlichung: https://www.nature.com/articles/s41598-020-64744-4
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-443839
hdl:20.500.11880/39669
http://dx.doi.org/10.22028/D291-44383
ISSN: 2045-2322
Datum des Eintrags: 14-Feb-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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