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Titel: Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration
VerfasserIn: Lababidi, Nashrawan
Sigal, Valentin
Koenneke, Aljoscha
Schwarzkopf, Konrad
Manz, Andreas
Schneider, Marc
Sprache: Englisch
Titel: Beilstein journal of nanotechnology
Bandnummer: 10
Seiten: 2280-2293
Verlag/Plattform: Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Erscheinungsjahr: 2019
Freie Schlagwörter: curcumin
human pulmonary mucus
microfluidics
muco-penetrating nanoparticles
nanomedicine
permeability
PLGA nanoparticles
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Great challenges still remain to develop drug carriers able to penetrate biological barriers (such as the dense mucus in cystic fibrosis) and for the treatment of bacteria residing in biofilms, embedded in mucus. Drug carrier systems such as nanoparticles (NPs) require proper surface chemistry and small size to ensure their permeability through the hydrogel-like systems. We have employed a microfluidic system to fabricate poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with a muco-penetrating stabilizer (Pluronic), with a tunable hydrodynamic diameter ranging from 40 nm to 160 nm. The size dependence was evaluated by varying different parameters during preparation, namely polymer concentration, stabilizer concentration, solvent nature, the width of the focus mixing channel, flow rate ratio and total flow rate. Furthermore, the influence of the length of the focus mixing channel on the size was evaluated in order to better understand the nucleation-growth mechanism. Surprisingly, the channel length was revealed to have no effect on particle size for the chosen settings. In addition, curcumin was loaded (EE% of ≈68%) very efficiently into the nanoparticles. Finally, the permeability of muco-penetrating PLGA NPs through pulmonary human mucus was assessed; small NPs with a diameter of less than 100 nm showed fast permeation, underlining the potential of microfluidics for such pharmaceutical applications.
DOI der Erstveröffentlichung: 10.3762/bjnano.10.220
URL der Erstveröffentlichung: https://www.beilstein-journals.org/bjnano/articles/10/220
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-443084
hdl:20.500.11880/39614
http://dx.doi.org/10.22028/D291-44308
ISSN: 2190-4286
Datum des Eintrags: 10-Feb-2025
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Marc Schneider
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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