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Titel: Quid Pro Quo! Organization Theoretical Remarks about FIFA’s Legitimacy Under Blatter and Infantino
VerfasserIn: Richau, Lukas
Emrich, Eike
Follert, Florian
Sprache: Englisch
Titel: The Economists' voice
Bandnummer: 16
Heft: 1
Seiten: 2280-2293
Verlag/Plattform: De Gruyter
Erscheinungsjahr: 2019
Freie Schlagwörter: curcumin
human pulmonary mucus
microfluidics
muco-penetrating nanoparticles
nanomedicine
permeability
PLGA nanoparticles
DDC-Sachgruppe: 796 Sport
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Great challenges still remain to develop drug carriers able to penetrate biological barriers (such as the dense mucus in cysticfibrosis) and for the treatment of bacteria residing in biofilms, embedded in mucus. Drug carrier systems such as nanoparticles (NPs) require proper surface chemistry and small size to ensure their permeability through the hydrogel-like systems. We have em ployed a microfluidic system to fabricate poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with a muco-penetrating stabi lizer (Pluronic), with a tunable hydrodynamic diameter ranging from 40 nm to 160 nm. The size dependence was evaluated by varying different parameters during preparation, namely polymer concentration, stabilizer concentration, solvent nature, the width of the focus mixing channel, flow rate ratio and total flow rate. Furthermore, the influence of the length of the focus mixing channel on the size was evaluated in order to better understand the nucleation–growth mechanism. Surprisingly, the channel length was revealed to have no effect on particle size for the chosen settings. In addition, curcumin was loaded (EE% of ≈68%) very effi ciently into the nanoparticles. Finally, the permeability of muco-penetrating PLGA NPs through pulmonary human mucus was assessed; small NPs with a diameter of less than 100 nm showed fast permeation, underlining the potential of microfluidics for such pharmaceutical applications.
DOI der Erstveröffentlichung: 10.1515/ev-2019-0014
URL der Erstveröffentlichung: https://www.degruyter.com/document/doi/10.1515/ev-2019-0014/html
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-443051
hdl:20.500.11880/39601
http://dx.doi.org/10.22028/D291-44305
ISSN: 1553-3832
Datum des Eintrags: 7-Feb-2025
Fakultät: HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft
Fachrichtung: HW - Sportwissenschaft
Professur: HW - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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