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Titel: Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs
VerfasserIn: Schaefer, Nadine
Kettner, Mattias
Laschke, Matthias W.
Schlote, Julia
Ewald, Andreas H.
Menger, Michael D.
Maurer, Hans H.
Schmidt, Peter H.
Sprache: Englisch
Titel: Current Neuropharmacology
Bandnummer: 15
Heft: 5
Seiten: 713-723
Verlag/Plattform: Bentham Science Publishers
Erscheinungsjahr: 2017
Freie Schlagwörter: Synthetic cannabinoids
tetrahydrocannabinol
pigs
tissue distribution
LC-MS/MS
pharmacokinetics
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Abstract: Background: Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1- pentyl-indol-3-yl)methanone (RCS-4) as well as ∆9-tetrahydrocannabinol (THC) as reference were examined in pigs. Methods: Pigs (n = 6 per drug) received a single intravenous 200 µg/kg BW dose of JWH-210, RCS4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. Results: The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination. Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection.
DOI der Erstveröffentlichung: 10.2174/1570159X15666161111114214
URL der Erstveröffentlichung: https://doi.org/10.2174/1570159x15666161111114214
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-442316
hdl:20.500.11880/39540
http://dx.doi.org/10.22028/D291-44231
ISSN: 1570-159X
Datum des Eintrags: 30-Jan-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
M - Experimentelle und Klinische Pharmakologie und Toxikologie
M - Rechtsmedizin
Professur: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Markus Meyer
M - Prof. Dr. Peter Schmidt
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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