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doi:10.22028/D291-44231
Titel: | Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs |
VerfasserIn: | Schaefer, Nadine Kettner, Mattias Laschke, Matthias W. Schlote, Julia Ewald, Andreas H. Menger, Michael D. Maurer, Hans H. Schmidt, Peter H. |
Sprache: | Englisch |
Titel: | Current Neuropharmacology |
Bandnummer: | 15 |
Heft: | 5 |
Seiten: | 713-723 |
Verlag/Plattform: | Bentham Science Publishers |
Erscheinungsjahr: | 2017 |
Freie Schlagwörter: | Synthetic cannabinoids tetrahydrocannabinol pigs tissue distribution LC-MS/MS pharmacokinetics |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Abstract: Background: Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1- pentyl-indol-3-yl)methanone (RCS-4) as well as ∆9-tetrahydrocannabinol (THC) as reference were examined in pigs. Methods: Pigs (n = 6 per drug) received a single intravenous 200 µg/kg BW dose of JWH-210, RCS4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. Results: The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination. Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection. |
DOI der Erstveröffentlichung: | 10.2174/1570159X15666161111114214 |
URL der Erstveröffentlichung: | https://doi.org/10.2174/1570159x15666161111114214 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-442316 hdl:20.500.11880/39540 http://dx.doi.org/10.22028/D291-44231 |
ISSN: | 1570-159X |
Datum des Eintrags: | 30-Jan-2025 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie M - Experimentelle und Klinische Pharmakologie und Toxikologie M - Rechtsmedizin |
Professur: | M - Prof. Dr. Michael D. Menger M - Prof. Dr. Markus Meyer M - Prof. Dr. Peter Schmidt |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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