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doi:10.22028/D291-44087
Title: | Axial alignment is a critical regulator of knee osteoarthritis |
Author(s): | Oláh, Tamás Reinhard, Jan Laschke, Matthias W. Goebel, Lars K. H. Walter, Frédéric Schmitt, Gertrud Speicher-Mentges, Susanne Menger, Michael D. Cucchiarini, Magali Pape, Dietrich Madry, Henning |
Language: | English |
Title: | Science Translational Medicine |
Volume: | 14 |
Issue: | 629 |
Publisher/Platform: | American Association for the Advancement of Science |
Year of Publication: | 2022 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment. By mapping response correlations at high resolution, we identify spatially complex degenerative changes in cartilage after overloading in a clinically relevant ovine model. We further report that unloading diminishes OA cartilage degeneration and alterations of critical parameters of the subchondral bone plate in a similar topographic fashion. Last, therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA. |
DOI of the first publication: | 10.1126/scitranslmed.abn0179 |
URL of the first publication: | https://www.science.org/doi/10.1126/scitranslmed.abn0179 |
Link to this record: | urn:nbn:de:bsz:291--ds-440876 hdl:20.500.11880/39438 http://dx.doi.org/10.22028/D291-44087 |
ISSN: | 1946-6242 1946-6234 |
Date of registration: | 22-Jan-2025 |
Description of the related object: | Supplementary Materials |
Related object: | https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_sm.pdf https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_data_files_s1_and_s2.zip https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_mdar_reproducibility_checklist.zip |
Faculty: | M - Medizinische Fakultät |
Department: | M - Chirurgie M - Orthopädie |
Professorship: | M - Prof. Dr. Henning Madry M - Prof. Dr. Michael D. Menger |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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