Please use this identifier to cite or link to this item: doi:10.22028/D291-44087
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Title: Axial alignment is a critical regulator of knee osteoarthritis
Author(s): Oláh, Tamás
Reinhard, Jan
Laschke, Matthias W.
Goebel, Lars K. H.
Walter, Frédéric
Schmitt, Gertrud
Speicher-Mentges, Susanne
Menger, Michael D.
Cucchiarini, Magali
Pape, Dietrich
Madry, Henning
Language: English
Title: Science Translational Medicine
Volume: 14
Issue: 629
Publisher/Platform: American Association for the Advancement of Science
Year of Publication: 2022
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment. By mapping response correlations at high resolution, we identify spatially complex degenerative changes in cartilage after overloading in a clinically relevant ovine model. We further report that unloading diminishes OA cartilage degeneration and alterations of critical parameters of the subchondral bone plate in a similar topographic fashion. Last, therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA.
DOI of the first publication: 10.1126/scitranslmed.abn0179
URL of the first publication: https://www.science.org/doi/10.1126/scitranslmed.abn0179
Link to this record: urn:nbn:de:bsz:291--ds-440876
hdl:20.500.11880/39438
http://dx.doi.org/10.22028/D291-44087
ISSN: 1946-6242
1946-6234
Date of registration: 22-Jan-2025
Description of the related object: Supplementary Materials
Related object: https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_sm.pdf
https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_data_files_s1_and_s2.zip
https://www.science.org/doi/suppl/10.1126/scitranslmed.abn0179/suppl_file/scitranslmed.abn0179_mdar_reproducibility_checklist.zip
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
M - Prof. Dr. Michael D. Menger
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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