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Titel: The vascularization paradox of non-union formation
VerfasserIn: Menger, Maximilian M.
Laschke, Matthias W.
Nussler, Andreas K.
Menger, Michael D.
Histing, Tina
Sprache: Englisch
Titel: Angiogenesis
Bandnummer: 25
Heft: 3
Seiten: 279-290
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2022
Freie Schlagwörter: Non-union
Vascularization
Angiogenesis
Bone healing
VEGF
Bone healing
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Despite major research eforts to elucidate mechanisms of non-union formation, failed fracture healing remains a common complication in orthopedic surgery. Adequate vascularization has been recognized as a crucial factor for successful bone regeneration, as newly formed microvessels guarantee the supply of the callus tissue with vital oxygen, nutrients, and growth factors. Accordingly, a vast number of preclinical studies have focused on the development of vascularization strategies to stimulate fracture repair. However, recent evidence suggests that stimulation of blood vessel formation is an oversimplifed approach to support bone regeneration. This review discusses the role of vascularization during bone regeneration and delineates a phenomenon, for which we coin the term “the vascularization paradox of non-union-formation”. This view is based on the results of a variety of experimental studies that suggest that the callus tissue of non-unions is indeed densely vascularized and that pro-angiogenic mediators, such as vascular endothelial growth factor, are sufciently expressed at the facture site. By gaining further insights into the molecular and cellular basis of non-union vascularization, it may be possible to develop more optimized treatment approaches or even prevent the non-union formation in the future.
DOI der Erstveröffentlichung: 10.1007/s10456-022-09832-x
URL der Erstveröffentlichung: https://link.springer.com/article/10.1007/s10456-022-09832-x
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-440798
hdl:20.500.11880/39433
http://dx.doi.org/10.22028/D291-44079
ISSN: 1573-7209
0969-6970
Datum des Eintrags: 22-Jan-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
Professur: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Tim Pohlemann
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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