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doi:10.22028/D291-44079
Titel: | The vascularization paradox of non-union formation |
VerfasserIn: | Menger, Maximilian M. Laschke, Matthias W. Nussler, Andreas K. Menger, Michael D. Histing, Tina |
Sprache: | Englisch |
Titel: | Angiogenesis |
Bandnummer: | 25 |
Heft: | 3 |
Seiten: | 279-290 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Non-union Vascularization Angiogenesis Bone healing VEGF Bone healing |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Despite major research eforts to elucidate mechanisms of non-union formation, failed fracture healing remains a common complication in orthopedic surgery. Adequate vascularization has been recognized as a crucial factor for successful bone regeneration, as newly formed microvessels guarantee the supply of the callus tissue with vital oxygen, nutrients, and growth factors. Accordingly, a vast number of preclinical studies have focused on the development of vascularization strategies to stimulate fracture repair. However, recent evidence suggests that stimulation of blood vessel formation is an oversimplifed approach to support bone regeneration. This review discusses the role of vascularization during bone regeneration and delineates a phenomenon, for which we coin the term “the vascularization paradox of non-union-formation”. This view is based on the results of a variety of experimental studies that suggest that the callus tissue of non-unions is indeed densely vascularized and that pro-angiogenic mediators, such as vascular endothelial growth factor, are sufciently expressed at the facture site. By gaining further insights into the molecular and cellular basis of non-union vascularization, it may be possible to develop more optimized treatment approaches or even prevent the non-union formation in the future. |
DOI der Erstveröffentlichung: | 10.1007/s10456-022-09832-x |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s10456-022-09832-x |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-440798 hdl:20.500.11880/39433 http://dx.doi.org/10.22028/D291-44079 |
ISSN: | 1573-7209 0969-6970 |
Datum des Eintrags: | 22-Jan-2025 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie |
Professur: | M - Prof. Dr. Michael D. Menger M - Prof. Dr. Tim Pohlemann |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s10456-022-09832-x.pdf | 2,84 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons