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Titel: Microvascular Fragments in Microcirculation Research and Regenerative Medicine
VerfasserIn: Laschke, Matthias W.
Menger, Michael D.
Sprache: Englisch
Titel: Tissue Engineering, Part B: Reviews
Bandnummer: 28
Heft: 5
Verlag/Plattform: Liebert
Erscheinungsjahr: 2022
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Adipose tissue-derived microvascular fragments (MVF) are functional vessel segments, which rapidly reassemble into new microvasculatures under experimental in vitro and in vivo conditions. Accordingly, they have been used for many years in microcirculation research to study basic mechanisms of endothelial cell function, angiogenesis, and microvascular network formation in two- and three-dimensional environments. Moreover, they serve as vascularization units for musculoskeletal regeneration and implanted biomaterials as well as for the treatment of myocardial infarction and the generation of prevascularized tissue organoids. Besides, multiple factors determining the vascularization capacity of MVF have been identified, including their tissue origin and cellular composition, the conditions for their short- and long-term storage, as well as their implantation site and the general health status and medication of the recipient. The next challenging step is now the successful translation of all these promising experimental findings into clinical practice. If this succeeds, a multitude of future therapeutic applications may significantly benefit from the remarkable properties of MVF.
DOI der Erstveröffentlichung: 10.1089/ten.teb.2021.0160
URL der Erstveröffentlichung: https://doi.org/10.1089/ten.teb.2021.0160
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-440569
hdl:20.500.11880/39411
http://dx.doi.org/10.22028/D291-44056
ISSN: 1937-3376
1937-3368
Datum des Eintrags: 21-Jan-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
Professur: M - Prof. Dr. Michael D. Menger
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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