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Titel: Perioperative Intermittent Fasting Protects Ischemic Musculocutaneous Flap Tissue from Necrosis
VerfasserIn: Weinzierl, Andrea
Harder, Yves
Menger, Michael D.
Laschke, Matthias W.
Sprache: Englisch
Titel: Plastic and Reconstructive Surgery
Bandnummer: 151 (2023)
Heft: 5
Seiten: 1030-1041
Verlag/Plattform: American Society of Plastic Surgeons
Erscheinungsjahr: 2022
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Dietary restriction, such as intermittent fasting (IF), has previously been shown to protect various tissues from ischemia-induced necrosis. Based on this finding, the authors herein evaluated for the first time the tissueprotective effects of IF in musculocutaneous flaps. Methods: Male C57BL/6N mice were randomly assigned to an IF group (n = 8) and a control group with unrestricted access to standard diet (n = 8). IF animals were put on a perioperative feeding schedule with 8 hours of unrestricted access to standard diet per day starting 7 days before flap elevation up to 3 days after surgery. Random pattern musculocutaneous flaps were raised and mounted into a dorsal skinfold chamber. Intravital fluorescence microscopy was performed on days 1, 3, 5, 7, and 10 after surgery for the quantitative assessment of angiogenesis, nutritive blood perfusion, and flap necrosis. After the in vivo observation period, the flaps were harvested for additional histologic and immunohistochemical analyses. Results: The authors found that the IF group exhibited more newly formed microvessels and a higher functional capillary density within the flap tissue when compared with controls. This was associated with a significantly lower rate of tissue necrosis. Immunohistochemical detection of different inflammatory cell subtypes revealed a markedly reduced number of invading myeloperoxidase-positive neutrophilic granulocytes in the musculocutaneous tissue of IF-treated animals. Conclusion: Considered together, these findings indicate that IF prevents flap necrosis by maintaining nutritive tissue perfusion and suppressing ischemiainduced inflammation. (Plast. Reconstr. Surg. 151: 1030, 2023.) Clinical Relevance Statement: Given the frequent use of flaps in plastic surgery and the high rates of ischemic complications, any new approach to decrease such complications is clinically relevant.
DOI der Erstveröffentlichung: 10.1097/PRS.0000000000010085
URL der Erstveröffentlichung: https://journals.lww.com/plasreconsurg/fulltext/2023/05000/perioperative_intermittent_fasting_protects.21.aspx
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-440540
hdl:20.500.11880/39409
http://dx.doi.org/10.22028/D291-44054
ISSN: 0032-1052
Datum des Eintrags: 21-Jan-2025
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
Professur: M - Prof. Dr. Michael D. Menger
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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