Ectopic Cushing Syndrome Localized by 68 Ga-DOTA-LM3 PET/CT

Abstract

A 53-year-old woman presented with signs of Cushing syndrome with challenges in diagnosis and localization. A novel somatostatin receptor (SSTR)–targeted PET/CT with 68Ga-DOTA-LM3, an SSTR antagonist, revealed a suspicious focal finding in the pancreatic head, proven to be ectopic Cushing syndrome after surgical resection. This interesting image clearly shows the potential of PET imaging with SSTR antagonists as 68Ga-DOTA-LM3 in the diagnosis of ectopic Cushing syndrome.