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doi:10.22028/D291-43837
Titel: | Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease |
VerfasserIn: | Stadler, Julia T. Borenich, Andrea Pammer, Anja Emrich, Insa E. Habisch, Hansjörg Madl, Tobias Heine, Gunnar H. Marsche, Gunther |
Sprache: | Englisch |
Titel: | Antioxidants |
Bandnummer: | 13 |
Heft: | 12 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2024 |
Freie Schlagwörter: | HDL subclasses chronic kidney disease survival lipoproteins mortality apolipoproteins |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | High-density lipoproteins (HDL) exist in various subclasses, with smaller HDL particles possessing the highest anti-oxidative and anti-inflammatory properties. Understanding the role of these specific subclasses in chronic kidney disease (CKD) could provide valuable insights into disease progression and potential therapeutic targets. In the present study, we assessed HDL subclass composition in 463 patients with CKD stage 2–4 using nuclear magnetic resonance spectroscopy. Over a mean follow-up period of 5.0 years, 18.6% of patients died. Compared to survivors, deceased patients exhibited significantly lower levels of cholesterol, ApoA-I, and ApoA-II within the small and extra-small (XS) HDL subclasses. Multivariable Cox regression analysis, adjusted for traditional cardiovascular and renal risk factors, demonstrated that reduced levels of XS-HDL-cholesterol, XS-HDL-ApoA-I, and XS-HDL-ApoA-II were independently associated with an increased risk of mortality. Furthermore, receiver operating characteristic analysis identified XS-HDL-ApoA-II as the most potent prognostic marker for mortality. In conclusion, reduced small and XS-HDL subclasses, especially XS-HDL-ApoA-II, are strongly associated with increased all-cause mortality risk in CKD patients. Assessment of HDL subclass distribution could provide valuable clinical information and help identify patients at high risk. |
DOI der Erstveröffentlichung: | 10.3390/antiox13121511 |
URL der Erstveröffentlichung: | https://doi.org/10.3390/antiox13121511 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-438377 hdl:20.500.11880/39321 http://dx.doi.org/10.22028/D291-43837 |
ISSN: | 2076-3921 |
Datum des Eintrags: | 9-Jan-2025 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Materials |
In Beziehung stehendes Objekt: | https://www.mdpi.com/article/10.3390/antiox13121511/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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antioxidants-13-01511.pdf | 869,64 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons