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doi:10.22028/D291-43902
Titel: | Comparison of R-CHOP-14 and R-mini-CHOP in older adults with diffuse large B-cell lymphoma-A retrospective multicenter cohort study |
VerfasserIn: | Dilbaz, Zelal Guel Denker, Sophy Ankermann, Carla Bittenbring, Joerg-Thomas Kaddu-Mulindwa, Dominic Kunte, Ameya S Hünecke, Sascha Poeschel, Viola Stilgenbauer, Stephan Thurner, Lorenz Na, Il-Kang Bewarder, Moritz Christofyllakis, Konstantinos |
Sprache: | Englisch |
Titel: | European Journal of Haematology |
Bandnummer: | 113 |
Heft: | 5 |
Seiten: | 675-684 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2024 |
Freie Schlagwörter: | aged 80 and over diffuse large B-cell lymphoma dose intensity R-CHOP-14 R-miniCHOP |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma entity, and its incidence increases with age. There is a paucity of data regarding use of biweekly R-CHOP (R-CHOP-14) in patients ≥80 years of age. We performed a retrospective cohort study of patients with DLBCL aged ≥80 years treated with R-CHOP-14 and R-miniCHOP in two academic tertiary centers in Germany between 01/01/2005 and 12/30/2019. Overall, 79 patients were included. Median age was 84 years (range 80–91). Despite higher CR rates with R-CHOP-14 (71.4% vs. 52.4%), no statistically significant difference could be found between patients treated with R-CHOP-14 and R-miniCHOP regarding overall survival (OS) (p = .88, HR 0.94, 95% CI = 0.47–1.90) and progression-free survival (PFS) (p = .26, HR 0.66, 95% CI = 0.32–1.36). At a median follow-up of 40 months, the 2-year OS rates were 56% with R-CHOP-14 and 53% with R-miniCHOP. Two-year PFS rates were 46% for R-CHOP-14 and 50% for R-mini-CHOP. Relative dose intensity of chemotherapy did not correlate with OS (p = .72). With the caveat of a retrospective cohort study, we conclude that lacking a difference in OS, R-miniCHOP should be preferred for most patients with untreated DLBCL aged ≥80 years. |
DOI der Erstveröffentlichung: | 10.1111/ejh.14268 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/10.1111/ejh.14268 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-439026 hdl:20.500.11880/39285 http://dx.doi.org/10.22028/D291-43902 |
ISSN: | 1600-0609 0902-4441 |
Datum des Eintrags: | 7-Jan-2025 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.14268&file=ejh14268-sup-0001-supinfo.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Stephan Stilgenbauer M - Dr. med. Lorenz Thurner |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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European J of Haematology - 2024 - Dilbaz - Comparison of R‐CHOP‐14 and R‐mini‐CHOP in older adults with diffuse large.pdf | 1,42 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons