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Titel: Comparison of R-CHOP-14 and R-mini-CHOP in older adults with diffuse large B-cell lymphoma-A retrospective multicenter cohort study
VerfasserIn: Dilbaz, Zelal Guel
Denker, Sophy
Ankermann, Carla
Bittenbring, Joerg-Thomas
Kaddu-Mulindwa, Dominic
Kunte, Ameya S
Hünecke, Sascha
Poeschel, Viola
Stilgenbauer, Stephan
Thurner, Lorenz
Na, Il-Kang
Bewarder, Moritz
Christofyllakis, Konstantinos
Sprache: Englisch
Titel: European Journal of Haematology
Bandnummer: 113
Heft: 5
Seiten: 675-684
Verlag/Plattform: Wiley
Erscheinungsjahr: 2024
Freie Schlagwörter: aged 80 and over
diffuse large B-cell lymphoma
dose intensity
R-CHOP-14
R-miniCHOP
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma entity, and its incidence increases with age. There is a paucity of data regarding use of biweekly R-CHOP (R-CHOP-14) in patients ≥80 years of age. We performed a retrospective cohort study of patients with DLBCL aged ≥80 years treated with R-CHOP-14 and R-miniCHOP in two academic tertiary centers in Germany between 01/01/2005 and 12/30/2019. Overall, 79 patients were included. Median age was 84 years (range 80–91). Despite higher CR rates with R-CHOP-14 (71.4% vs. 52.4%), no statistically significant difference could be found between patients treated with R-CHOP-14 and R-miniCHOP regarding overall survival (OS) (p = .88, HR 0.94, 95% CI = 0.47–1.90) and progression-free survival (PFS) (p = .26, HR 0.66, 95% CI = 0.32–1.36). At a median follow-up of 40 months, the 2-year OS rates were 56% with R-CHOP-14 and 53% with R-miniCHOP. Two-year PFS rates were 46% for R-CHOP-14 and 50% for R-mini-CHOP. Relative dose intensity of chemotherapy did not correlate with OS (p = .72). With the caveat of a retrospective cohort study, we conclude that lacking a difference in OS, R-miniCHOP should be preferred for most patients with untreated DLBCL aged ≥80 years.
DOI der Erstveröffentlichung: 10.1111/ejh.14268
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/10.1111/ejh.14268
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-439026
hdl:20.500.11880/39285
http://dx.doi.org/10.22028/D291-43902
ISSN: 1600-0609
0902-4441
Datum des Eintrags: 7-Jan-2025
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.14268&file=ejh14268-sup-0001-supinfo.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Stephan Stilgenbauer
M - Dr. med. Lorenz Thurner
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons