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doi:10.22028/D291-43775
Titel: | Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord |
VerfasserIn: | Gobbo, Davide Rieder, Phillip Fang, Li-Pao Buttigieg, Emeline Schablowski, Moritz Damo, Elisa Bosche, Nathalie Dallorto, Eleonora May, Pascal Bai, Xianshu Kirchhoff, Frank Scheller, Anja |
Sprache: | Englisch |
Titel: | Cells |
Bandnummer: | 13 |
Heft: | 23 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2024 |
Freie Schlagwörter: | spinal cord GABAB receptors oligodendrocyte precursor cells demyelination cuprizone |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor cells (OPCs) respond to injuries and neurodegenerative diseases like multiple sclerosis. Taking advantage of the temporally controlled and cell-specific genetic downregulation of GABAB receptors from OPCs, our investigation addresses their specific influence on OPC behavior in the gray and white matter of the mouse spinal cord. Our results show that, while GABAB receptors do not significantly alter spinal cord myelination under physiological conditions, they distinctly regulate the OPC differentiation and Ca2+ signaling. In addition, we investigate the impact of OPC-GABAB receptors in two models of toxic demyelination, namely, the cuprizone and the lysolecithin models. The genetic downregulation of OPC-GABAB receptors protects against demyelination and oligodendrocyte loss. Additionally, we observe the enhanced resilience to cuprizone-induced pathological alterations in OPC Ca2+ signaling. Our results provide valuable insights into the potential therapeutic implications of manipulating GABAB receptors in spinal cord OPCs and deepen our understanding of the interplay between GABAergic signaling and spinal cord OPCs, providing a basis for future research. |
DOI der Erstveröffentlichung: | 10.3390/cells13232014 |
URL der Erstveröffentlichung: | https://doi.org/10.3390/cells13232014 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-437751 hdl:20.500.11880/39195 http://dx.doi.org/10.22028/D291-43775 |
ISSN: | 2073-4409 |
Datum des Eintrags: | 16-Dez-2024 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Materials |
In Beziehung stehendes Objekt: | https://www.mdpi.com/article/10.3390/cells13232014/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Physiologie |
Professur: | M - Prof. Dr. Frank Kirchhoff |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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cells-13-02014-v3.pdf | 18,37 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons