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Titel: Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis
VerfasserIn: Kaddu-Mulindwa, Dominic
Heit, Matthias
Wagenpfeil, Gudrun
Bewarder, Moritz
Fassbender, Klaus
Behnke, Stefanie
Yilmaz, Umut
Fousse, Mathias
Sprache: Englisch
Titel: Frontiers in Neurology
Bandnummer: 13
Verlag/Plattform: Frontiers
Erscheinungsjahr: 2022
Freie Schlagwörter: HIV
third ventricle diameter
transcranial ultrasound
HIV associated neurocognitive disorders
fractional anisotropy
CERAD-PLUS
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Despite antiretroviral therapy, cognitive dysfunction seems to remain a major issue for people living with human immunodeficiency virus (PLWH). Previous studies showed a correlation between the width of the third ventricle (WTV) and neurocognitive disorders in PLWH. Patients and methods: We investigated prevalence and correlation of neuropsychological disorders using WTV as a brain atrophy marker examined by transcranial sonography and MRI in PLWH and healthy age- and gender-matched controls. We used Becks Depression Inventory (BDI) for depression screening, the questionnaires Fatigue Severity Scale (FSS) for fatigue and Short-Form-36 (SF36) for quality of life (QoL) evaluation and Consortium to establish a registry for Alzheimer's disease (CERAD-PLUS) as neuropsychological test battery. Results: 52 PLWH (47 males) and 28 non-infected controls (23 males) with a median age of 52 years (24–78 years) and 51 years (22–79) were analyzed. WTV correlated significantly with age (p < 0.01) but showed no significantly difference in PLWH (median = 3.4 mm) compared to healthy controls (median = 2.8 mm) (p = 0.085). PLWH had both significantly higher BDI-Scores (p = 0.005) and FSS-Scores (p = 0.012). Controls reported higher QoL (SF-36) with significant differences in most items. However, the overall cognitive performance (CERAD total score) showed no significant difference. The WTV of all subjects correlated with neurocognitive performance measured as CERAD total score (p = 0.009) and trail making tests A (p < 0.001) and B (p = 0.018). There was no correlation between the scores of BDI, FSS, SF-36, and CERAD-PLUS items and WTV. Conclusion: WTV is considered as a predictor of cognitive deficits in neurodegenerative diseases. Nevertheless, we found no significant difference in WTV or overall cognitive performance between PLWH and controls. PLWH suffer more often from depression and fatigue and report reduced QoL when compared to healthy controls.
DOI der Erstveröffentlichung: 10.3389/fneur.2022.962535
URL der Erstveröffentlichung: https://doi.org/10.3389/fneur.2022.962535
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-437080
hdl:20.500.11880/39147
http://dx.doi.org/10.22028/D291-43708
ISSN: 1664-2295
Datum des Eintrags: 10-Dez-2024
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Neurologie und Psychiatrie
M - Radiologie
Professur: M - Prof. Dr. Klaus Faßbender
M - Dr. med. Lorenz Thurner
M - Prof. Dr. Stefan Wagenpfeil
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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