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doi:10.22028/D291-43708
Titel: | Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis |
VerfasserIn: | Kaddu-Mulindwa, Dominic Heit, Matthias Wagenpfeil, Gudrun Bewarder, Moritz Fassbender, Klaus Behnke, Stefanie Yilmaz, Umut Fousse, Mathias |
Sprache: | Englisch |
Titel: | Frontiers in Neurology |
Bandnummer: | 13 |
Verlag/Plattform: | Frontiers |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | HIV third ventricle diameter transcranial ultrasound HIV associated neurocognitive disorders fractional anisotropy CERAD-PLUS |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Despite antiretroviral therapy, cognitive dysfunction seems to remain a major issue for people living with human immunodeficiency virus (PLWH). Previous studies showed a correlation between the width of the third ventricle (WTV) and neurocognitive disorders in PLWH. Patients and methods: We investigated prevalence and correlation of neuropsychological disorders using WTV as a brain atrophy marker examined by transcranial sonography and MRI in PLWH and healthy age- and gender-matched controls. We used Becks Depression Inventory (BDI) for depression screening, the questionnaires Fatigue Severity Scale (FSS) for fatigue and Short-Form-36 (SF36) for quality of life (QoL) evaluation and Consortium to establish a registry for Alzheimer's disease (CERAD-PLUS) as neuropsychological test battery. Results: 52 PLWH (47 males) and 28 non-infected controls (23 males) with a median age of 52 years (24–78 years) and 51 years (22–79) were analyzed. WTV correlated significantly with age (p < 0.01) but showed no significantly difference in PLWH (median = 3.4 mm) compared to healthy controls (median = 2.8 mm) (p = 0.085). PLWH had both significantly higher BDI-Scores (p = 0.005) and FSS-Scores (p = 0.012). Controls reported higher QoL (SF-36) with significant differences in most items. However, the overall cognitive performance (CERAD total score) showed no significant difference. The WTV of all subjects correlated with neurocognitive performance measured as CERAD total score (p = 0.009) and trail making tests A (p < 0.001) and B (p = 0.018). There was no correlation between the scores of BDI, FSS, SF-36, and CERAD-PLUS items and WTV. Conclusion: WTV is considered as a predictor of cognitive deficits in neurodegenerative diseases. Nevertheless, we found no significant difference in WTV or overall cognitive performance between PLWH and controls. PLWH suffer more often from depression and fatigue and report reduced QoL when compared to healthy controls. |
DOI der Erstveröffentlichung: | 10.3389/fneur.2022.962535 |
URL der Erstveröffentlichung: | https://doi.org/10.3389/fneur.2022.962535 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-437080 hdl:20.500.11880/39147 http://dx.doi.org/10.22028/D291-43708 |
ISSN: | 1664-2295 |
Datum des Eintrags: | 10-Dez-2024 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Neurologie und Psychiatrie M - Radiologie |
Professur: | M - Prof. Dr. Klaus Faßbender M - Dr. med. Lorenz Thurner M - Prof. Dr. Stefan Wagenpfeil M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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fneur-13-962535.pdf | 2,69 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons