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doi:10.22028/D291-43654 | Title: | Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models |
| Author(s): | Rox, Katharina Jansen, Rolf Lukežič, Tadeja Greweling-Pils, Marina Herrmann, Jennifer Miethke, Marcus Hüttel, Stephan Hennessen, Fabienne Abou Fayad, Antoine Holzhausen, Cornelia Lundberg, Carina Vingsbo Teague, Joanne Sudarman, Enge Bülter, Lisa Hesterkamp, Thomas Stadler, Marc Brönstrup, Mark Müller, Rolf |
| Language: | English |
| Title: | Microbiology spectrum |
| Volume: | 12 |
| Issue: | 1 |
| Publisher/Platform: | ASM |
| Year of Publication: | 2023 |
| DDC notations: | 500 Science |
| Publikation type: | Journal Article |
| Abstract: | There is a strong need to find novel treatment options against urinary tract infections associated with antimicrobial resistance. This study evaluates two atypical tetracyclines, namely chelocardin (CHD) and amidochelocardin (CDCHD), with respect to their pharmacokinetics and pharmacodynamics. We show CHD and CDCHD are cleared at high concentrations in mouse urine. Especially, CDCHD is highly effective in an ascending urinary tract infection model, suggesting further preclinical evaluation. |
| DOI of the first publication: | 10.1128/spectrum.01289-23 |
| URL of the first publication: | https://journals.asm.org/doi/10.1128/spectrum.01289-23 |
| Link to this record: | urn:nbn:de:bsz:291--ds-436547 hdl:20.500.11880/39117 http://dx.doi.org/10.22028/D291-43654 |
| ISSN: | 2165-0497 |
| Date of registration: | 4-Dec-2024 |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Pharmazie |
| Professorship: | NT - Prof. Dr. Rolf Müller |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| rox-et-al-2023-pharmacokinetic-and-pharmacodynamic-evaluation-of-the-atypical-tetracyclines-chelocardin-and.pdf | 3,38 MB | Adobe PDF | View/Open |
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