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Titel: Combinatorial Host-Response Biomarker Signature (BV Score) and Its Subanalytes TRAIL, IP-10, and C-Reactive Protein in Children With Mycoplasma pneumoniae Community-Acquired Pneumonia
VerfasserIn: Papan, Cihan
Sidorov, Semjon
Greiter, Beat
Bühler, Nina
Berger, Christoph
Becker, Sören L.
Meyer Sauteur, Patrick M.
Sprache: Englisch
Titel: The Journal of Infectious Diseases
Bandnummer: 230 (2024)
Heft: 2
Seiten: e247-e253
Verlag/Plattform: Oxford University Press
Erscheinungsjahr: 2023
Freie Schlagwörter: Mycoplasma pneumoniae
community-acquired pneumonia
TRAIL
IP-10
host response biomarkers
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background. Host-response biomarkers to differentiate bacterial from viral etiology in children with respiratory infections have shown high accuracies, but are understudied in Mycoplasma pneumoniae (Mp) infections. Methods. We compared BV scores (0–34 indicating viral etiology, and 66–100 indicating bacterial etiology), tumor necrosis factor–related apoptosis-inducing ligand (TRAIL; pg/mL), interferon-γ inducible protein 10 (IP-10; pg/mL), and C-reactive protein (CRP; mg/L) serum levels between Mp-positive (Mp+ ) and Mp-negative (Mp−) community-acquired pneumonia (CAP) patients. We performed receiver operating characteristic (ROC) curve analyses for clinical features and biomarkers. Results. Of 80 CAP patients (median age, 6.3 years; 57.5% male), 26 had Mp+ CAP. In Mp+ CAP patients, compared to Mp−CAP patients, BV scores were lower (14.0 [3.0–27.8] vs 54.0 [12.0–84.8]; P = .0008), TRAIL levels were higher (86.5 [67.4–123.0] vs 65.5 [42.5–103.9]; P = .025), CRP levels were lower (12.9 [4.0–22.3] vs 36.7 [13.0–132.8]; P = .0019), and IP-10 levels were comparable (366.0 [150.2–603.8] vs 331.0 [154.3–878.8]; P = .73) (all median [interquartile range]). ROC analyses yielded a comparable discriminatory accuracy for the combination of age, fever duration, and duration of respiratory symptoms, with either procalcitonin or BV score (area under the ROC curve, 0.87 vs 0.86; P = .94). Conclusions. Children with Mp+ CAP have atypically low, viral levels of the BV score, underscoring the complementary role of microbiological testing.
DOI der Erstveröffentlichung: 10.1093/infdis/jiad573
URL der Erstveröffentlichung: https://doi.org/10.1093/infdis/jiad573
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-434778
hdl:20.500.11880/38972
http://dx.doi.org/10.22028/D291-43477
ISSN: 1537-6613
0022-1899
Datum des Eintrags: 18-Nov-2024
Bezeichnung des in Beziehung stehenden Objekts: Supplementary data
In Beziehung stehendes Objekt: https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/230/2/10.1093_infdis_jiad573/1/jiad573_supplementary_data.docx?Expires=1734938371&Signature=GKo~JsSoA3IJrfeBwKBch7irlGMfTWzml0mg6PO7AZkVd4Qf9wEub9ELhvyFGD4~ez948AkkZTWLMglK12p6EP~fJSEZa3NyJcTUkoKvFIU-ASKjc~cxEPQSLaXaifSHwSr0NuK3iiPXfvLWF5h8zcGUM1RLOZyj1F6lLsgoePA4k~d3I4pYQGbljQSAqSFp~nzpW0rWWLDT1qxSKC1ypcZa4tW3UXVWME~fCGa~sDIbl9hHy4ZMXjpJOOEybr5QFq6-18O8-NBLH425EvlDQiXl4i1hq9RgQTHG-B2564wM3Mo-QB1F7dH0v5ezny1WuMycAFIV4nsb5aYorV9sjA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
Professur: M - Prof. Dr. Sören Becker
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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