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doi:10.22028/D291-43477
Titel: | Combinatorial Host-Response Biomarker Signature (BV Score) and Its Subanalytes TRAIL, IP-10, and C-Reactive Protein in Children With Mycoplasma pneumoniae Community-Acquired Pneumonia |
VerfasserIn: | Papan, Cihan Sidorov, Semjon Greiter, Beat Bühler, Nina Berger, Christoph Becker, Sören L. Meyer Sauteur, Patrick M. |
Sprache: | Englisch |
Titel: | The Journal of Infectious Diseases |
Bandnummer: | 230 (2024) |
Heft: | 2 |
Seiten: | e247-e253 |
Verlag/Plattform: | Oxford University Press |
Erscheinungsjahr: | 2023 |
Freie Schlagwörter: | Mycoplasma pneumoniae community-acquired pneumonia TRAIL IP-10 host response biomarkers |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background. Host-response biomarkers to differentiate bacterial from viral etiology in children with respiratory infections have shown high accuracies, but are understudied in Mycoplasma pneumoniae (Mp) infections. Methods. We compared BV scores (0–34 indicating viral etiology, and 66–100 indicating bacterial etiology), tumor necrosis factor–related apoptosis-inducing ligand (TRAIL; pg/mL), interferon-γ inducible protein 10 (IP-10; pg/mL), and C-reactive protein (CRP; mg/L) serum levels between Mp-positive (Mp+ ) and Mp-negative (Mp−) community-acquired pneumonia (CAP) patients. We performed receiver operating characteristic (ROC) curve analyses for clinical features and biomarkers. Results. Of 80 CAP patients (median age, 6.3 years; 57.5% male), 26 had Mp+ CAP. In Mp+ CAP patients, compared to Mp−CAP patients, BV scores were lower (14.0 [3.0–27.8] vs 54.0 [12.0–84.8]; P = .0008), TRAIL levels were higher (86.5 [67.4–123.0] vs 65.5 [42.5–103.9]; P = .025), CRP levels were lower (12.9 [4.0–22.3] vs 36.7 [13.0–132.8]; P = .0019), and IP-10 levels were comparable (366.0 [150.2–603.8] vs 331.0 [154.3–878.8]; P = .73) (all median [interquartile range]). ROC analyses yielded a comparable discriminatory accuracy for the combination of age, fever duration, and duration of respiratory symptoms, with either procalcitonin or BV score (area under the ROC curve, 0.87 vs 0.86; P = .94). Conclusions. Children with Mp+ CAP have atypically low, viral levels of the BV score, underscoring the complementary role of microbiological testing. |
DOI der Erstveröffentlichung: | 10.1093/infdis/jiad573 |
URL der Erstveröffentlichung: | https://doi.org/10.1093/infdis/jiad573 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-434778 hdl:20.500.11880/38972 http://dx.doi.org/10.22028/D291-43477 |
ISSN: | 1537-6613 0022-1899 |
Datum des Eintrags: | 18-Nov-2024 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary data |
In Beziehung stehendes Objekt: | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/230/2/10.1093_infdis_jiad573/1/jiad573_supplementary_data.docx?Expires=1734938371&Signature=GKo~JsSoA3IJrfeBwKBch7irlGMfTWzml0mg6PO7AZkVd4Qf9wEub9ELhvyFGD4~ez948AkkZTWLMglK12p6EP~fJSEZa3NyJcTUkoKvFIU-ASKjc~cxEPQSLaXaifSHwSr0NuK3iiPXfvLWF5h8zcGUM1RLOZyj1F6lLsgoePA4k~d3I4pYQGbljQSAqSFp~nzpW0rWWLDT1qxSKC1ypcZa4tW3UXVWME~fCGa~sDIbl9hHy4ZMXjpJOOEybr5QFq6-18O8-NBLH425EvlDQiXl4i1hq9RgQTHG-B2564wM3Mo-QB1F7dH0v5ezny1WuMycAFIV4nsb5aYorV9sjA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Infektionsmedizin |
Professur: | M - Prof. Dr. Sören Becker |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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jiad573.pdf | 656,61 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons