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doi:10.22028/D291-43468
Titel: | Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies |
VerfasserIn: | Fricke, Janis Schalk, Felix Kreuzenbeck, Nina B. Seibel, Elena Hoffmann, Judith Dittmann, Georg Conlon, Benjamin H. Guo, Huijuan Wilhelm de Beer, Z. Vassão, Daniel Giddings Gleixner, Gerd Poulsen, Michael Beemelmanns, Christine |
Sprache: | Englisch |
Titel: | The ISME journal : multidisciplinary journal of microbial ecology |
Bandnummer: | 17 |
Heft: | 5 |
Seiten: | 733-747 |
Verlag/Plattform: | Nature Publishing Group |
Erscheinungsjahr: | 2023 |
DDC-Sachgruppe: | 500 Naturwissenschaften |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Characterizing ancient clades of fungal symbionts is necessary for understanding the evolutionary process underlying symbiosis development. In this study, we investigated a distinct subgeneric taxon of Xylaria (Xylariaceae), named Pseudoxylaria, whose members have solely been isolated from the fungus garden of farming termites. Pseudoxylaria are inconspicuously present in active fungus gardens of termite colonies and only emerge in the form of vegetative stromata, when the fungus comb is no longer attended ("sit and wait" strategy). Insights into the genomic and metabolic consequences of their association, however, have remained sparse. Capitalizing on viable Pseudoxylaria cultures from different termite colonies, we obtained genomes of seven and transcriptomes of two Pseudoxylaria isolates. Using a whole-genome-based comparison with free-living members of the genus Xylaria, we document that the association has been accompanied by significant reductions in genome size, protein-coding gene content, and reduced functional capacities related to oxidative lignin degradation, oxidative stress responses and secondary metabolite production. Functional studies based on growth assays and fungus-fungus co-cultivations, coupled with isotope fractionation analysis, showed that Pseudoxylaria only moderately antagonizes growth of the termite food fungus Termitomyces, and instead extracts nutrients from the food fungus biomass for its own growth. We also uncovered that Pseudoxylaria is still capable of producing structurally unique metabolites, which was exemplified by the isolation of two novel metabolites, and that the natural product repertoire correlated with antimicrobial and insect antifeedant activity. |
DOI der Erstveröffentlichung: | 10.1038/s41396-023-01374-4 |
URL der Erstveröffentlichung: | https://www.nature.com/articles/s41396-023-01374-4 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-434686 hdl:20.500.11880/38965 http://dx.doi.org/10.22028/D291-43468 |
ISSN: | 1751-7370 1751-7362 |
Datum des Eintrags: | 14-Nov-2024 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Pharmazie |
Professur: | NT - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s41396-023-01374-4.pdf | 4,59 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons