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Titel: Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement
VerfasserIn: Recktenwald, Steffen M.
Rashidi, Yazdan
Graham, Ian
Arratia, Paulo E.
Del Giudice, Francesco
Wagner, Christian
Sprache: Englisch
Titel: Soft Matter
Bandnummer: 20
Heft: 25
Seiten: 4950-4963
Verlag/Plattform: Royal Society of Chemistry
Erscheinungsjahr: 2024
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Red blood cells (RBC), the primary carriers of oxygen in the body, play a crucial role across several biomedical applications, while also being an essential model system of a deformable object in the microfluidics and soft matter fields. However, RBC behavior in viscoelastic liquids, which holds promise in enhancing microfluidic diagnostic applications, remains poorly studied. We here show that using viscoelastic polymer solutions as a suspending carrier causes changes in the clustering and shape of flowing RBC in microfluidic flows when compared to a standard Newtonian suspending liquid. Additionally, when the local RBC concentration increases to a point where hydrodynamic interactions take place, we observe the formation of equally-spaced RBC structures, resembling the viscoelasticity-driven ordered particles observed previously in the literature, thus providing the first experimental evidence of viscoelasticity-driven cell ordering. The observed RBC ordering, unaffected by polymer molecular architecture, persists as long as the surrounding medium exhibits shear-thinning, viscoelastic properties. Complementary numerical simulations reveal that viscoelasticity-induced repulsion between RBCs leads to equidistant structures, with shearthinning modulating this effect. Our results open the way for the development of new biomedical technologies based on the use of viscoelastic liquids while also clarifying fundamental aspects related to multibody hydrodynamic interactions in viscoelastic microfluidic flows.
DOI der Erstveröffentlichung: 10.1039/D4SM00446A
URL der Erstveröffentlichung: https://doi.org/10.1039/D4SM00446A
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-432511
hdl:20.500.11880/38782
http://dx.doi.org/10.22028/D291-43251
ISSN: 1744-6848
1744-683X
Datum des Eintrags: 23-Okt-2024
Bezeichnung des in Beziehung stehenden Objekts: Electronic supplementary information
In Beziehung stehendes Objekt: https://www.rsc.org/suppdata/d4/sm/d4sm00446a/d4sm00446a1.pdf
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Physik
Professur: NT - Prof. Dr. Christian Wagner
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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