Please use this identifier to cite or link to this item: doi:10.22028/D291-42635
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Title: Lingering Dynamics in Microvascular Blood Flow
Author(s): Kihm, Alexander
Quint, Stephan
Laschke, Matthias W.
Menger, Michael D.
John, Thomas
Kaestner, Lars
Wagner, Christian
Language: English
Title: Biophysical Journal
Volume: 120 (2021)
Issue: 3
Pages: 432-439
Publisher/Platform: Cell Press
Year of Publication: 2020
DDC notations: 500 Science
610 Medicine and health
Publikation type: Journal Article
Abstract: The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of red blood cells (RBCs) through these networks ensures the gas exchange in as well as the transport of nutrients to the tissues. Any alterations in this blood flow may have severe implications on the health state. Because the vessels in these networks obey dimensions similar to the diameter of RBCs, dynamic effects on the cellular scale play a key role. The steady progression in the numerical modeling of RBCs, even in complex networks, has led to novel findings in the field of hemodynamics, especially concerning the impact and the dynamics of lingering events when a cell meets a branch of the network. However, these results are yet to be matched by a detailed analysis of the lingering experiments in vivo. To quantify this lingering effect in in vivo experiments, this study analyzes branching vessels in the microvasculature of Syrian golden hamsters via intravital microscopy and the use of an implanted dorsal skinfold chamber. It also presents a detailed analysis of these lingering effects of cells at the apex of bifurcating vessels, affecting the temporal distribution of plasmatic zones of blood flow in the branches and even causing a partial blockage in severe cases.
DOI of the first publication: 10.1016/j.bpj.2020.12.012
URL of the first publication: https://doi.org/10.1016/j.bpj.2020.12.012
Link to this record: urn:nbn:de:bsz:291--ds-426354
hdl:20.500.11880/38238
http://dx.doi.org/10.22028/D291-42635
ISSN: 0006-3495
Date of registration: 12-Aug-2024
Description of the related object: Supporting Material
Related object: https://ars.els-cdn.com/content/image/1-s2.0-S0006349520332173-mmc1.pdf
https://ars.els-cdn.com/content/image/1-s2.0-S0006349520332173-mmc6.pdf
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Chirurgie
NT - Physik
Professorship: M - Prof. Dr. Michael D. Menger
NT - Prof. Dr. Christian Wagner
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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